NCTR1_RAT
ID NCTR1_RAT Reviewed; 325 AA.
AC Q9Z0H5;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Natural cytotoxicity triggering receptor 1;
DE AltName: Full=Activating receptor 1;
DE Short=rAR-1;
DE AltName: Full=Lymphocyte antigen 94 homolog;
DE AltName: Full=NK receptor KILR-1;
DE AltName: Full=NKACTR;
DE AltName: Full=Natural killer cell p46-related protein;
DE Short=NK-p46;
DE Short=NKp46;
DE AltName: CD_antigen=CD335;
DE Flags: Precursor;
GN Name=Ncr1; Synonyms=Ar1, Kilr1, Ly94;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Lymphoid tissue;
RX PubMed=10424451; DOI=10.1016/s0165-2478(99)00052-8;
RA Falco M., Cantoni C., Bottino C., Moretta A., Biassoni R.;
RT "Identification of the rat homologue of the human NKp46 triggering
RT receptor.";
RL Immunol. Lett. 68:411-414(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=PVG;
RA Berg S.F., Dissen E., Westgaard I.H., Fossum S.;
RT "Molecular characterization of KILR-1, a novel immunoglobulin-like gene in
RT the rat, expressed by NK cells.";
RL Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Cytotoxicity-activating receptor that may contribute to the
CC increased efficiency of activated natural killer (NK) cells to mediate
CC tumor cell lysis. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CD3Z and FCER1G. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Weakly expressed in spleen, heart and lung.
CC {ECO:0000269|PubMed:10424451}.
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000305}.
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DR EMBL; AJ012741; CAA10161.1; -; mRNA.
DR EMBL; AF082533; AAC69890.1; -; mRNA.
DR RefSeq; NP_476547.1; NM_057199.1.
DR AlphaFoldDB; Q9Z0H5; -.
DR SMR; Q9Z0H5; -.
DR STRING; 10116.ENSRNOP00000025080; -.
DR GlyGen; Q9Z0H5; 2 sites.
DR PhosphoSitePlus; Q9Z0H5; -.
DR PaxDb; Q9Z0H5; -.
DR GeneID; 117547; -.
DR KEGG; rno:117547; -.
DR UCSC; RGD:621288; rat.
DR CTD; 9437; -.
DR RGD; 621288; Ncr1.
DR VEuPathDB; HostDB:ENSRNOG00000027855; -.
DR eggNOG; ENOG502RWVC; Eukaryota.
DR HOGENOM; CLU_021100_1_1_1; -.
DR InParanoid; Q9Z0H5; -.
DR OMA; TGMYDIP; -.
DR OrthoDB; 1327293at2759; -.
DR PhylomeDB; Q9Z0H5; -.
DR TreeFam; TF336644; -.
DR PRO; PR:Q9Z0H5; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000018458; Expressed in spleen and 6 other tissues.
DR Genevisible; Q9Z0H5; RN.
DR GO; GO:0009986; C:cell surface; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051607; P:defense response to virus; ISO:RGD.
DR GO; GO:0009597; P:detection of virus; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..325
FT /note="Natural cytotoxicity triggering receptor 1"
FT /id="PRO_0000015030"
FT TOPO_DOM 17..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..325
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 42..100
FT /note="Ig-like 1"
FT DOMAIN 137..192
FT /note="Ig-like 2"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..98
FT /evidence="ECO:0000250|UniProtKB:O76036"
FT DISULFID 144..190
FT /evidence="ECO:0000250|UniProtKB:O76036"
SQ SEQUENCE 325 AA; 37178 MW; 502C10AA02F65FA4 CRC64;
MLPTLTALLC LGLCLSQRIN TEKQTLPKPI IWAKPSIMVT KGNSVNIWCQ GAQSASEYQL
YFEGSFFALE RPKSSRSMNK VKFFISQMTS HTAGIYTCFY QSGELWSESS NPLKLVVTGL
YDTPTLWVHP GPEVTLGENV TFSCHLKTAT SKFFLLKERE SNHIQHKYGN IQAEFPMGPV
TRAHRGTYRC FGSYNDYAWS FPSEPVTLLI TGEVENTSLA PTDPVSSLDY WEFDLSTKES
GLQKDSAFWD HTAQNLIRIG LACIIVMALV WLLAEDWLSR RKDHEKLNRL TSWECRGRRR
MHRYHEEEQR DAISMRELKA TPGDM
