NCTR3_MACMU
ID NCTR3_MACMU Reviewed; 201 AA.
AC Q8MJ02; Q5TM24; Q8MJ00; Q8MJ01; Q95JB8;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Natural cytotoxicity triggering receptor 3;
DE AltName: Full=Natural killer cell p30-related protein;
DE Short=NK-p30;
DE Short=NKp30;
DE AltName: CD_antigen=CD337;
DE Flags: Precursor;
GN Name=NCR3;
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544;
RN [1]
RP NUCLEOTIDE SEQUENCE (ISOFORMS 1; 2; 3 AND 4), AND VARIANT VAL-156.
RA LaBonte M.L., Miller J., Letvin N.L.;
RT "Molecular cloning of rhesus monkey NKp46 and NKp30 and identification of
RT NKp46SD and NKp30S.";
RL Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE (ISOFORMS 1 AND 4), AND VARIANT VAL-156.
RC TISSUE=Lymphoid tissue;
RA Rizzi M., Biassoni R.;
RT "NCR express by macaca NK cells.";
RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 5).
RX PubMed=15269276; DOI=10.1093/molbev/msh216;
RA Kulski J.K., Anzai T., Shiina T., Inoko H.;
RT "Rhesus macaque class I duplicon structures, organization, and evolution
RT within the alpha block of the major histocompatibility complex.";
RL Mol. Biol. Evol. 21:2079-2091(2004).
CC -!- FUNCTION: Cell membrane receptor of natural killer/NK cells that is
CC activated by binding of extracellular ligands including BAG6 and
CC NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells
CC producing these ligands. It controls, for instance, NK cells
CC cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also
CC promotes myeloid dendritic cells (DC) maturation, both through killing
CC DCs that did not acquire a mature phenotype, and inducing the release
CC by NK cells of TNFA and IFNG that promote DC maturation.
CC {ECO:0000250|UniProtKB:O14931}.
CC -!- SUBUNIT: Homodimer in the unliganted form. Interacts with CD3Z.
CC Interacts with and is activated by binding to NCR3LG1. Interacts with
CC and is activated by binding to BAG6. {ECO:0000250|UniProtKB:O14931}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O14931};
CC Single-pass type I membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=5;
CC IsoId=Q8MJ02-5; Sequence=Displayed;
CC Name=1;
CC IsoId=Q8MJ02-1; Sequence=VSP_013641, VSP_013642;
CC Name=2;
CC IsoId=Q8MJ02-2; Sequence=VSP_010414;
CC Name=3;
CC IsoId=Q8MJ02-3; Sequence=VSP_010415, VSP_010416;
CC Name=4;
CC IsoId=Q8MJ02-4; Sequence=VSP_010417;
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000305}.
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DR EMBL; AY035214; AAK63116.1; -; mRNA.
DR EMBL; AY035215; AAK63117.1; -; mRNA.
DR EMBL; AY035216; AAK63118.1; -; mRNA.
DR EMBL; AY035217; AAK63119.1; -; mRNA.
DR EMBL; AJ554301; CAD86942.1; -; mRNA.
DR EMBL; AB128049; BAD69721.1; -; Genomic_DNA.
DR RefSeq; NP_001036105.1; NM_001042640.1. [Q8MJ02-1]
DR RefSeq; XP_014991417.1; XM_015135931.1.
DR AlphaFoldDB; Q8MJ02; -.
DR SMR; Q8MJ02; -.
DR STRING; 9544.ENSMMUP00000011616; -.
DR Ensembl; ENSMMUT00000012386; ENSMMUP00000011616; ENSMMUG00000008854. [Q8MJ02-5]
DR Ensembl; ENSMMUT00000092524; ENSMMUP00000079012; ENSMMUG00000008854. [Q8MJ02-2]
DR GeneID; 715574; -.
DR KEGG; mcc:715574; -.
DR CTD; 259197; -.
DR VEuPathDB; HostDB:ENSMMUG00000008854; -.
DR eggNOG; ENOG502SGFD; Eukaryota.
DR GeneTree; ENSGT00390000006603; -.
DR HOGENOM; CLU_132406_0_0_1; -.
DR InParanoid; Q8MJ02; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000008854; Expressed in spleen and 10 other tissues.
DR ExpressionAtlas; Q8MJ02; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002429; P:immune response-activating cell surface receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0030101; P:natural killer cell activation; ISS:UniProtKB.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR043226; NCR3.
DR PANTHER; PTHR47904; PTHR47904; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Disulfide bond; Glycoprotein;
KW Immunity; Immunoglobulin domain; Membrane; Receptor; Reference proteome;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..201
FT /note="Natural cytotoxicity triggering receptor 3"
FT /id="PRO_0000015034"
FT TOPO_DOM 19..133
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..201
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 19..126
FT /note="Ig-like"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 39..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 66..90
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_010414"
FT VAR_SEQ 112..115
FT /note="VLGL -> NILS (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_010415"
FT VAR_SEQ 116..201
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_010416"
FT VAR_SEQ 167..180
FT /note="LTWKGPRRQLPAVV -> HCHMGTHCHSSDGP (in isoform 1)"
FT /evidence="ECO:0000305"
FT /id="VSP_013641"
FT VAR_SEQ 177..201
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_010417"
FT VAR_SEQ 181..201
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000305"
FT /id="VSP_013642"
FT VARIANT 156
FT /note="M -> V"
FT /evidence="ECO:0000269|Ref.1, ECO:0000269|Ref.2"
SQ SEQUENCE 201 AA; 21684 MW; AE3A325C8585BA68 CRC64;
MAWMLLLILI MVYPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV
APGKEVRNGT PEFRGRLAPL SSSRFLRDHQ AELHIWDVRG HDAGIYVCRV EVLGLGVGTG
NGTRLVVEKE YPQLGAGTVL LLRAGFYAVS FLSVAMGSTL YYQGKCLTWK GPRRQLPAVV
PGPLPPPCGS SAHLLPPVPG G
