NCTR3_RAT
ID NCTR3_RAT Reviewed; 192 AA.
AC Q8CFD9; Q80WM8; Q8CG11;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 2.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Natural cytotoxicity triggering receptor 3;
DE AltName: Full=Natural killer cell p30-related protein;
DE Short=NK-p30;
DE Short=NKp30;
DE AltName: CD_antigen=CD337;
DE Flags: Precursor;
GN Name=Ncr3; Synonyms=1c7;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE, AND VARIANTS VAL-7; VAL-19; VAL-82 AND THR-138.
RC STRAIN=PVG; TISSUE=Natural killer cell;
RX PubMed=12548565; DOI=10.1002/immu.200310008;
RA Backman-Petersson E., Miller J.R., Hollyoake M., Aguado B., Butcher G.W.;
RT "Molecular characterization of the novel rat NK receptor 1C7.";
RL Eur. J. Immunol. 33:342-351(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Lewis;
RX PubMed=12180816; DOI=10.1016/s0966-3274(02)00033-3;
RA Hsieh C.L., Obara H., Ogura Y., Martinez O.M., Krams S.M.;
RT "NK cells and transplantation.";
RL Transpl. Immunol. 9:111-114(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15060004; DOI=10.1101/gr.1987704;
RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT "The genomic sequence and comparative analysis of the rat major
RT histocompatibility complex.";
RL Genome Res. 14:631-639(2004).
CC -!- FUNCTION: Cell membrane receptor of natural killer/NK cells that is
CC activated by binding of extracellular ligands including BAG6 and
CC NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells
CC producing these ligands. It controls, for instance, NK cells
CC cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also
CC promotes myeloid dendritic cells (DC) maturation, both through killing
CC DCs that did not acquire a mature phenotype, and inducing the release
CC by NK cells of TNFA and IFNG that promote DC maturation.
CC {ECO:0000250|UniProtKB:O14931}.
CC -!- SUBUNIT: Homodimer in the unliganted form. Interacts with CD3Z.
CC Interacts with and is activated by binding to NCR3LG1. Interacts with
CC and is activated by binding to BAG6. {ECO:0000250|UniProtKB:O14931}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O14931};
CC Single-pass type I membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the natural cytotoxicity receptor (NCR) family.
CC {ECO:0000305}.
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DR EMBL; AJ430418; CAD23066.1; -; mRNA.
DR EMBL; AJ430419; CAD23067.2; -; Genomic_DNA.
DR EMBL; AJ430420; CAD23067.2; JOINED; Genomic_DNA.
DR EMBL; AY273824; AAP13457.1; -; mRNA.
DR EMBL; BX883046; CAE84000.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8CFD9; -.
DR SMR; Q8CFD9; -.
DR STRING; 10116.ENSRNOP00000001139; -.
DR GlyGen; Q8CFD9; 2 sites.
DR PaxDb; Q8CFD9; -.
DR UCSC; RGD:727881; rat.
DR RGD; 727881; Ncr3.
DR eggNOG; ENOG502SGFD; Eukaryota.
DR InParanoid; Q8CFD9; -.
DR PhylomeDB; Q8CFD9; -.
DR TreeFam; TF337790; -.
DR PRO; PR:Q8CFD9; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:0002429; P:immune response-activating cell surface receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0030101; P:natural killer cell activation; ISS:UniProtKB.
DR GO; GO:0045954; P:positive regulation of natural killer cell mediated cytotoxicity; ISO:RGD.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR043226; NCR3.
DR PANTHER; PTHR47904; PTHR47904; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW Immunoglobulin domain; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..192
FT /note="Natural cytotoxicity triggering receptor 3"
FT /id="PRO_0000015036"
FT TOPO_DOM 19..147
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 19..126
FT /note="Ig-like"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 39..108
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VARIANT 7
FT /note="I -> V"
FT /evidence="ECO:0000269|PubMed:12548565"
FT VARIANT 19
FT /note="I -> V"
FT /evidence="ECO:0000269|PubMed:12548565"
FT VARIANT 82
FT /note="A -> V"
FT /evidence="ECO:0000269|PubMed:12548565"
FT VARIANT 138
FT /note="A -> T"
FT /evidence="ECO:0000269|PubMed:12548565"
FT CONFLICT 135
FT /note="A -> V (in Ref. 2; AAP13457)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 192 AA; 20470 MW; 7FC84FB252D22377 CRC64;
MAKVLLIVFI MVYAGSCAIW VSQPPEIRAQ EGTTASLPCS FNASRGKAAI GSATWYQDKV
APGMELSNVT PGFRGRVASF SASQFIRGHK AGLLIQDIQS HDARIYVCRV EVLGLGVGTG
NGTRLVVEKE PPQQASNAEP ERAAYTSLLL RAGVYALSFL SVATGSVIYY QGKCLCHVGN
TATPPTASEE RF
