ID   NCTSP_BPN4              Reviewed;        1382 AA.
AC   A0MZE7;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   23-FEB-2022, entry version 32.
DE   RecName: Full=Non-contractile tail sheath;
DE   AltName: Full=Gene product 65;
DE            Short=Gp65;
GN   Name=65;
OS   Enterobacteria phage N4 (Bacteriophage N4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Schitoviridae; Enquatrovirinae; Enquatrovirus.
OX   NCBI_TaxID=10752;
OH   NCBI_TaxID=562; Escherichia coli.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Hendrix R.W., Rothman-Denes L., Hatfull G.F., Lawrence J.G., Pedulla M.;
RT   "Genome sequence and analysis of bacteriophage N4.";
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   ELECTRON MICROSCOPY (14 ANGSTROMS) OF COMPLETE VIRION, FUNCTION, AND
RP   SUBCELLULAR LOCATION.
RX   PubMed=18374942; DOI=10.1016/j.jmb.2008.02.059;
RA   Choi K.H., McPartland J., Kaganman I., Bowman V.D., Rothman-Denes L.B.,
RA   Rossmann M.G.;
RT   "Insight into DNA and protein transport in double-stranded DNA viruses: the
RT   structure of bacteriophage N4.";
RL   J. Mol. Biol. 378:726-736(2008).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH E.COLI NFRA.
RX   PubMed=19011026; DOI=10.1128/jb.01423-08;
RA   McPartland J., Rothman-Denes L.B.;
RT   "The tail sheath of bacteriophage N4 interacts with the Escherichia coli
RT   receptor.";
RL   J. Bacteriol. 191:525-532(2009).
CC   -!- FUNCTION: Assembles to form the non-contractile sheath that surrounds
CC       the tail tube (PubMed:18374942). Allows viral attachment to the host by
CC       binding the bacterial outer membrane protein NfrA (PubMed:19011026).
CC       {ECO:0000269|PubMed:18374942, ECO:0000269|PubMed:19011026}.
CC   -!- SUBUNIT: Interacts with host NfrA receptor; this interaction is
CC       essential for viral adsorption to the host.
CC       {ECO:0000269|PubMed:19011026}.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000269|PubMed:18374942}.
CC       Note=Present in about 6 copies in the virion.
CC       {ECO:0000269|PubMed:18374942}.
CC   -!- MISCELLANEOUS: It is uncommon for short-tailed phages to have a tail
CC       tube inside a non-contractile sheath. {ECO:0000305}.
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DR   EMBL; EF056009; ABK54426.1; -; Genomic_DNA.
DR   RefSeq; YP_950543.1; NC_008720.1.
DR   GeneID; 5075714; -.
DR   KEGG; vg:5075714; -.
DR   Proteomes; UP000001789; Genome.
DR   GO; GO:0098015; C:virus tail; IEA:UniProtKB-KW.
DR   GO; GO:0098671; P:adhesion receptor-mediated virion attachment to host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Host-virus interaction; Reference proteome;
KW   Viral attachment to host adhesion receptor; Viral attachment to host cell;
KW   Viral tail protein; Virion; Virus entry into host cell.
FT   CHAIN           1..1382
FT                   /note="Non-contractile tail sheath"
FT                   /id="PRO_0000436253"
SQ   SEQUENCE   1382 AA;  154117 MW;  A6E9D322147B01AA CRC64;
     MSIEDYLKGK NCLASPNYDP DDQHSSWRED LPQFKKDREH LTLVNTRRNR TYNTKLNRFD
     PEYWVVDYNA LMVATIIPYG SKSFKVPCQW RTNKDFLGVR WMTEDTFDHH LYRYETDPNY
     LGLILAFRHN PDEPDKFTVT IQTPEKAYTY RLAPYGFNNK TRRWECLDTK YGTKRTYQAD
     IFVATDEDIP ESEMTEVYGT KDYIFILDFA DLRTGVAFNG VTINPRNITM ISFDCTEAHH
     GLGKDAYIAA MYNNDDGATF QMEIGGIHTN AALAAGDKLQ CIWRYLDVNG NAQAAENEFE
     VVSYEGFGTS NFSVKCKGML PGKFIGCDAF YGKYLQTDGP IKQVDSVKWF TNLTVSGSGR
     KQLGQRKYPQ VVMGMGMTSG FDDGYNLTPE RQVKMAYGLG YRDWWTTYIG MSHYWKGLTA
     FQDKETGELI TEQTVLDYPI LFAGESQVAI HFMSGAYPDR GYDVFQKYMT ETWGINYAGV
     HPINGTTGST AVDRACAVNP NSEVFDPTQS SGAGGLWWWD LEADKPGPAL LHCVGQVGKL
     KPKAIIWGQG DQDATALAYP GDRNPAPSLT RTKQATKKVF EYLRSLYGQI PIFIQELSYA
     WGITNTDAPN VPIRTGLPSF LAARRNTWGD IEFRWKSYGL DPALAQYRIE IYNPSNLNQI
     LHSFVVSGTQ EANGYVYADF TVEDWIPVMM EAVGSPNPWE FMKWRVVCLY QEREIPSAPW
     SDNIPLDNAG LVKKTILVGI NQFGGGHFTD MSDPTATTAN GAIGRKDKVS ASTLRLTFAE
     KAGLRPIQVM PVNVAADSAG MTVGTHKWWN TSSNSPGDAL LAINDMVKGL GVKPDYFIEA
     NPWETMYMKD VNSSTWPALM TAFESSNKAM LAWMRTNWGN PNLEIWFQGA TTVWFGVAPP
     NDLNSEATVT VRDKQIQMAT ANIGFKLGSF VPGSNLYTAY RNVESSWIYY TVEAFHATAI
     ELGEALALNI NRATNPPDWS YLRPPANLQG RKLATRDIKM TWDNRAGITH WKYANRHVTT
     GAEISSGILT SPEYVFTLND QQNAYNGDTL NMSFSVSEYA ADSGAVGASS SFVGVVQNGS
     YMQTPTQLKA AKQLNGDIIF TWVGRPSWQH FWVVNTSVND SKTVIFSKEW SSESLTWTVA
     EQNEFYGLEE GGATHVIFMV SEYDPSNGLV SIGAQVTGQA EQPSNPMNPV AGLYAVFTGD
     PGNSNIKIMW DKPSVGGRDV RIRNMHVTSS ATISDQFVSD NNLVFTREEQ VAAYGFTASS
     VSVRAQEHDI ESGALGLTTE YVAVPETAGT VGQGFAKKDS VGNCTMSWEV GDAVQWQVEI
     LNAENSTVVK TEIVVAPTIT WMAEEITAEY GYLTDHMVWR VRPYRADGAS NVAKQFDMTA
     TL