NCX6_CAEEL
ID NCX6_CAEEL Reviewed; 590 AA.
AC P34315;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 3.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Putative sodium/calcium exchanger 6;
DE AltName: Full=Na(+)/Ca(2+)-exchange protein 6;
DE Flags: Precursor;
GN Name=ncx-6; ORFNames=C07A9.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000305}.
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DR EMBL; Z29094; CAA82339.3; -; Genomic_DNA.
DR PIR; S40705; S40705.
DR RefSeq; NP_499146.2; NM_066745.2.
DR AlphaFoldDB; P34315; -.
DR STRING; 6239.C07A9.4; -.
DR PaxDb; P34315; -.
DR PeptideAtlas; P34315; -.
DR EnsemblMetazoa; C07A9.4.1; C07A9.4.1; WBGene00003571.
DR GeneID; 182354; -.
DR KEGG; cel:CELE_C07A9.4; -.
DR UCSC; C07A9.4; c. elegans.
DR CTD; 182354; -.
DR WormBase; C07A9.4; CE33595; WBGene00003571; ncx-6.
DR eggNOG; KOG2399; Eukaryota.
DR GeneTree; ENSGT00970000196614; -.
DR HOGENOM; CLU_004979_3_1_1; -.
DR InParanoid; P34315; -.
DR OMA; IYLWQAV; -.
DR OrthoDB; 478735at2759; -.
DR PhylomeDB; P34315; -.
DR PRO; PR:P34315; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003571; Expressed in adult organism and 1 other tissue.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IBA:GO_Central.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006812; P:cation transport; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport; Calcium; Calcium transport; Ion transport; Membrane;
KW Reference proteome; Signal; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..590
FT /note="Putative sodium/calcium exchanger 6"
FT /id="PRO_0000019386"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 368..388
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 440..460
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 499..519
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 535..555
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 568..588
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 590 AA; 66170 MW; E5085F6B8178E444 CRC64;
MRIHFFAFLI ILSLVGCDGW QADVGKLVRK WNNQRTIDGN DIEKCIPDDG EQCTIQAGWN
STQVCEYVKC NDDNCEGGGY VLWTRYVECA SSPAVRIILI ITGVIYMLVL FIMVSSAADD
FFSPSISSIV AHLRISESVA GVTFMAFGNG APDVFGAIAS VLSSPTPKAD LALGELFGAG
LFVTTMVLAV TIFTRPFKAE VFSSIRDIAF YLVALAFLAF CFVYYDHVEI WMPITFLGVY
LIYVCTVILS QILHNRHKKD EEKVDEVKTV DTDSLEDDDD IYVSHGHHVL HAHEVMKMEA
EIEAVEPLKT WSFRGVVHDF KEHLKPWPSM DEWDEMNIFQ KVIAVLNTIP NFLFKLTIPH
SEQPWSKPIT LLQCLICPVF LLFCIQVCSI SPFPNSPGLW MYGLILSVLL TAAVLFFTEL
HKEPPFYKSL ISYAGFLMSI AWIYLISSEV VNVVTMLGVV SRVSHEVLGL TILAWSNSIG
DLIADVSVAK QGYPRMAMAA AIGGQLFNLL IGFGLPFTIA KIQGKSISMI INPTYRLLML
FLAISLIFTL IAMFAQKYFL RRIHSYSLVF IYISFFVFIG LSLDDILVWN
