NCX7_CAEEL
ID NCX7_CAEEL Reviewed; 672 AA.
AC P34322;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Putative sodium/calcium exchanger 7;
DE AltName: Full=Na(+)/Ca(2+)-exchange protein 7;
DE Flags: Precursor;
GN Name=ncx-7; ORFNames=C07A9.11;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. {ECO:0000305}.
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DR EMBL; Z29094; CAA82341.3; -; Genomic_DNA.
DR PIR; S40707; S40707.
DR RefSeq; NP_499147.3; NM_066746.6.
DR AlphaFoldDB; P34322; -.
DR STRING; 6239.C07A9.11; -.
DR EPD; P34322; -.
DR PaxDb; P34322; -.
DR PeptideAtlas; P34322; -.
DR EnsemblMetazoa; C07A9.11.1; C07A9.11.1; WBGene00003572.
DR GeneID; 176370; -.
DR KEGG; cel:CELE_C07A9.11; -.
DR UCSC; C07A9.11; c. elegans.
DR CTD; 176370; -.
DR WormBase; C07A9.11; CE39219; WBGene00003572; ncx-7.
DR eggNOG; KOG2399; Eukaryota.
DR GeneTree; ENSGT00970000196614; -.
DR HOGENOM; CLU_004979_3_1_1; -.
DR InParanoid; P34322; -.
DR OMA; MNIANEV; -.
DR OrthoDB; 478735at2759; -.
DR PhylomeDB; P34322; -.
DR Reactome; R-CEL-425561; Sodium/Calcium exchangers.
DR Reactome; R-CEL-8949215; Mitochondrial calcium ion transport.
DR PRO; PR:P34322; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003572; Expressed in larva and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005432; F:calcium:sodium antiporter activity; IBA:GO_Central.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006812; P:cation transport; IBA:GO_Central.
DR GO; GO:0006874; P:cellular calcium ion homeostasis; IBA:GO_Central.
DR Gene3D; 1.20.1420.30; -; 2.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport; Calcium; Calcium transport; Ion transport; Membrane;
KW Reference proteome; Signal; Sodium; Sodium transport; Transmembrane;
KW Transmembrane helix; Transport.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..672
FT /note="Putative sodium/calcium exchanger 7"
FT /id="PRO_0000019387"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 522..542
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 551..571
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 581..601
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 620..640
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 649..669
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 672 AA; 74824 MW; 79FBB91D80959A35 CRC64;
MAQPSILFSL TLIFLISIKS CDAKYRTSFF KTPNCSIYPD AEKCELNKTW TQEQVCDYVN
CNDNACEGGG YLLWTQYVEC ASSTFSRVIL IIVGVIYMLV LFIMVSSAAD DFFSPSISSI
VAHLRISESV AGVTFMAFGN GAPDVFGSIA SVLSSPTPKA DLALGELFGG GLFVTTMVVS
TIILTSPFDV EVFSTIRDLL FYLVALSFLA FCFVFYNRVT LWMPLTFLGL YLLYVITVIG
AQAVHNRKRK ALQKQNSTKS RKSIKSLRSR KSIHSVAPMP VIPEIEVHDQ EAPFPEISVV
TGAIDKLKEH MAEKAQTTRR YTKRASFMVN GDGNLNGLHP YATHNHLGIS RRESELSDED
EEFVVIHGHV FQGHEARSRA ASLVPEPMQI KSWRSKDILK DLAEHLDPRP EAEDWEEMNI
FSKVMAYINV VPNLLFKLTI PLNEMSWSKP LTLLHAFTCP AFLLFSIQFF LETPFSGSPG
LWVYGLAVSI VLAILIMVFT ELSVQPKYYK EIYSYSGFIM SIAWIYLISS EVVNVVTMLG
VVSRVSHEVL GLTILAWSNS IGDLIADVSV VKQGYPRMAM AAAIGGPLFN LLMGFGLPFT
IAKLQGKYIS MTINPTYRLL ILFLAISLLA TLIGIPVQKF RLQRPHAAVL ISIYIAFIVF
VILSETGVLV WN
