NDADA_ARATH
ID NDADA_ARATH Reviewed; 143 AA.
AC Q8RWA7; O23022; Q8GX35;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13-A;
DE AltName: Full=Protein MATERNAL EFFECT EMBRYO ARREST 4;
GN Name=MEE4; OrderedLocusNames=At1g04630; ORFNames=T1G11.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-72.
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Complex I is composed of at least 49 different subunits.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}; Matrix side {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA13 subunit family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB80637.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002376; AAB80637.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27724.1; -; Genomic_DNA.
DR EMBL; AY093225; AAM13224.1; -; mRNA.
DR EMBL; BT002116; AAN72127.1; -; mRNA.
DR EMBL; AK118461; BAC43069.1; -; mRNA.
DR PIR; A86179; A86179.
DR RefSeq; NP_171957.2; NM_100342.4.
DR PDB; 7A23; EM; 3.70 A; Z=1-143.
DR PDB; 7A24; EM; 3.80 A; Z=1-143.
DR PDB; 7AQQ; EM; 3.06 A; Z=1-143.
DR PDB; 7AQR; EM; 2.91 A; Z=1-143.
DR PDB; 7AR7; EM; 3.72 A; Z=19-143.
DR PDB; 7AR8; EM; 3.53 A; Z=1-143.
DR PDB; 7ARB; EM; 3.41 A; Z=1-143.
DR PDBsum; 7A23; -.
DR PDBsum; 7A24; -.
DR PDBsum; 7AQQ; -.
DR PDBsum; 7AQR; -.
DR PDBsum; 7AR7; -.
DR PDBsum; 7AR8; -.
DR PDBsum; 7ARB; -.
DR AlphaFoldDB; Q8RWA7; -.
DR SMR; Q8RWA7; -.
DR BioGRID; 24700; 9.
DR STRING; 3702.AT1G04630.1; -.
DR TCDB; 3.D.1.6.3; the h(+) or na(+)-translocating nadh dehydrogenase (ndh) family.
DR MetOSite; Q8RWA7; -.
DR PaxDb; Q8RWA7; -.
DR PRIDE; Q8RWA7; -.
DR ProteomicsDB; 250997; -.
DR EnsemblPlants; AT1G04630.1; AT1G04630.1; AT1G04630.
DR GeneID; 839465; -.
DR Gramene; AT1G04630.1; AT1G04630.1; AT1G04630.
DR KEGG; ath:AT1G04630; -.
DR Araport; AT1G04630; -.
DR TAIR; locus:2197833; AT1G04630.
DR eggNOG; KOG3300; Eukaryota.
DR HOGENOM; CLU_119720_2_0_1; -.
DR InParanoid; Q8RWA7; -.
DR OMA; WEVGTYY; -.
DR OrthoDB; 1496781at2759; -.
DR PhylomeDB; Q8RWA7; -.
DR PRO; PR:Q8RWA7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8RWA7; baseline and differential.
DR GO; GO:0005576; C:extracellular region; HDA:TAIR.
DR GO; GO:0031966; C:mitochondrial membrane; IDA:TAIR.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; HDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0045271; C:respiratory chain complex I; IDA:TAIR.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0009853; P:photorespiration; TAS:TAIR.
DR InterPro; IPR009346; GRIM-19.
DR PANTHER; PTHR12966; PTHR12966; 1.
DR Pfam; PF06212; GRIM-19; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Reference proteome; Respiratory chain;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..143
FT /note="NADH dehydrogenase [ubiquinone] 1 alpha subcomplex
FT subunit 13-A"
FT /id="PRO_0000410935"
FT TRANSMEM 43..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 7
FT /note="R -> G (in Ref. 4; BAC43069)"
FT /evidence="ECO:0000305"
FT HELIX 48..80
FT /evidence="ECO:0007829|PDB:7AQQ"
FT TURN 81..85
FT /evidence="ECO:0007829|PDB:7AQQ"
FT HELIX 86..111
FT /evidence="ECO:0007829|PDB:7AQQ"
FT HELIX 140..142
FT /evidence="ECO:0007829|PDB:7AQQ"
SQ SEQUENCE 143 AA; 16126 MW; 050BC50A45CB9F9D CRC64;
MTEAMIRNKP GMASVKDMPL LQDGPPPGGF APVRYARRIS NTGPSAMAMF LAVSGAFAWG
MYQVGQGNKI RRALKEEKYA ARRTILPILQ AEEDERFVSE WKKYLEYEAD VMKDVPGWKV
GENVYNSGRW MPPATGELRP DVW
