ID   NDB12_BUTOI             Reviewed;          21 AA.
AC   Q9TWD3;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Bradykinin-potentiating peptide K12 {ECO:0000303|PubMed:8745044};
DE            Short=BPP-K12 {ECO:0000303|PubMed:8745044};
DE            Short=Peptide K-12 {ECO:0000303|PubMed:8745044};
DE   AltName: Full=Non-disulfide-bridged peptide 1.2 {ECO:0000303|PubMed:24184590, ECO:0000303|PubMed:8745044};
DE            Short=NDBP-1.2 {ECO:0000303|PubMed:24184590, ECO:0000303|PubMed:8745044};
OS   Buthus occitanus (Common European scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Buthus.
OX   NCBI_TaxID=6868;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=8745044; DOI=10.1016/0196-9781(95)02036-5;
RA   Meki A.R., Nassar A.Y., Rochat H.;
RT   "A bradykinin-potentiating peptide (peptide K12) isolated from the venom of
RT   Egyptian scorpion Buthus occitanus.";
RL   Peptides 16:1359-1365(1995).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24184590; DOI=10.1016/j.peptides.2013.10.021;
RA   Almaaytah A., Albalas Q.;
RT   "Scorpion venom peptides with no disulfide bridges: a review.";
RL   Peptides 51:35-45(2014).
CC   -!- FUNCTION: Inhibits angiotensin-converting enzyme (ACE), but does not
CC       serve as substrate for the enzyme. Potentiate bradykinin (BK) on the
CC       isolated guinea pig ileum as well as the isolated rat uterus for
CC       contraction. Also potentiates in vivo the depressor effect of BK on
CC       arterial blood pressure in the normotensive anesthetized rat.
CC       Intracerebroventricular injection into mice does not show toxic
CC       activity. {ECO:0000269|PubMed:8745044}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8745044}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2137.3; Mass_error=0.3; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:8745044};
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Scorpion BPP (group 1) family. {ECO:0000305}.
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DR   AlphaFoldDB; Q9TWD3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Secreted.
FT   PEPTIDE         1..21
FT                   /note="Bradykinin-potentiating peptide K12"
FT                   /id="PRO_0000343192"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   21 AA;  2137 MW;  2D43D186B33852C4 CRC64;
     LRDYANRVIN GGPVEAAGPP A