ID   NDB21_HOFAZ             Reviewed;          41 AA.
AC   P82656;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Hadrurin {ECO:0000303|PubMed:10931184};
DE   AltName: Full=Non-disulfide-bridged peptide 2.1 {ECO:0000303|PubMed:24184590};
DE            Short=NDBP-2.1 {ECO:0000303|PubMed:24184590};
DE   AltName: Full=Non-disulfide-bridged peptide 3.1 {ECO:0000303|PubMed:16036557};
DE            Short=NDBP-3.1 {ECO:0000303|PubMed:16036557};
OS   Hoffmannihadrurus aztecus (Mexican scorpion) (Hadrurus aztecus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Iuroidea; Hadrurus.
OX   NCBI_TaxID=132263;
RN   [1]
RP   PROTEIN SEQUENCE, SYNTHESIS, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=10931184; DOI=10.1046/j.1432-1327.2000.01556.x;
RA   Torres-Larios A., Gurrola G.B., Zamudio F.Z., Possani L.D.;
RT   "Hadrurin, a new antimicrobial peptide from the venom of the scorpion
RT   Hadrurus aztecus.";
RL   Eur. J. Biochem. 267:5023-5031(2000).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=16036557; DOI=10.1080/15216540500058899;
RA   Zeng X.C., Corzo G., Hahin R.;
RT   "Scorpion venom peptides without disulfide bridges.";
RL   IUBMB Life 57:13-21(2005).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=24184590; DOI=10.1016/j.peptides.2013.10.021;
RA   Almaaytah A., Albalas Q.;
RT   "Scorpion venom peptides with no disulfide bridges: a review.";
RL   Peptides 51:35-45(2014).
CC   -!- FUNCTION: Antimicrobial activity against S.typhimurium, K.pneumoniae,
CC       E.cloacae, P.aeruginosa, E.coli and S.marcescens. Also shows hemolytic
CC       activity when tested in human erythrocytes.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10931184}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Long chain multifunctional peptide (group 2) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P82656; -.
DR   SMR; P82656; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR012526; Antimicrobial_7.
DR   Pfam; PF08102; Antimicrobial_7; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Cytolysis; Direct protein sequencing; Hemolysis;
KW   Secreted.
FT   CHAIN           1..41
FT                   /note="Hadrurin"
FT                   /id="PRO_0000152878"
SQ   SEQUENCE   41 AA;  4436 MW;  65D00C96FE27F978 CRC64;
     GILDTIKSIA SKVWNSKTVQ DLKRKGINWV ANKLGVSPQA A