ID   NDB2_HETSP              Reviewed;          83 AA.
AC   A0A0C4G489;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2015, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=Heterin-1 {ECO:0000303|PubMed:24389272};
DE   Flags: Precursor;
OS   Heterometrus spinifer (Asia giant forest scorpion) (Malaysian black
OS   scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Heterometrinae;
OC   Heterometrus.
OX   NCBI_TaxID=118530;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, AND SYNTHESIS OF 23-65.
RX   PubMed=24389272; DOI=10.1016/j.peptides.2013.12.012;
RA   Wu S., Nie Y., Zeng X.C., Cao H., Zhang L., Zhou L., Yang Y., Luo X.,
RA   Liu Y.;
RT   "Genomic and functional characterization of three new venom peptides from
RT   the scorpion Heterometrus spinifer.";
RL   Peptides 53:30-41(2014).
CC   -!- FUNCTION: Amphipathic peptide with potent activities against both Gram-
CC       positive and Gram-negative bacteria. Is the most active against the two
CC       Gram-positive Bacillus megaterium and Micrococcus luteus (MIC=4.0 uM
CC       for both). It has relatively low hemolytic activity against human
CC       erythrocytes. {ECO:0000269|PubMed:24389272}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:24389272}. Target
CC       cell membrane {ECO:0000305|PubMed:24389272}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:24389272}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Long chain multifunctional peptide (group 2) family.
CC       {ECO:0000305}.
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DR   EMBL; KC538867; AGK88593.1; -; mRNA.
DR   EMBL; KC538868; AGK88594.1; -; Genomic_DNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR012526; Antimicrobial_7.
DR   Pfam; PF08102; Antimicrobial_7; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Fungicide; Ion transport; Membrane; Secreted;
KW   Signal; Target cell membrane; Target membrane; Transmembrane; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..65
FT                   /note="Heterin-1"
FT                   /evidence="ECO:0000305|PubMed:24389272"
FT                   /id="PRO_5007393300"
FT   PROPEP          66..83
FT                   /evidence="ECO:0000305|PubMed:24389272"
FT                   /id="PRO_0000454583"
SQ   SEQUENCE   83 AA;  9245 MW;  2F596E12CA36D6EC CRC64;
     MNGKLLLVSL MVTMLVMQPA EAGVWDWLKK TAKNVWNSDI VKQLKGKAIN AAKNYVAEKI
     GATPSVAGQI PFDEFMDILH YRP