NDB2_MESEU
ID NDB2_MESEU Reviewed; 75 AA.
AC P86407; E4VP02;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-2015, sequence version 2.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Meucin-49 {ECO:0000303|Ref.2};
DE AltName: Full=Venom antimicrobial peptide {ECO:0000303|Ref.1};
DE Short=VAMP-1 {ECO:0000303|Ref.1};
DE Flags: Precursor;
OS Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX NCBI_TaxID=34648;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Zhu S., Gao B.;
RT "Molecular characterization of a venom antimicrobial peptide from
RT Mesobuthus eupeus (MeVAMP-1).";
RL Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 23-71, FUNCTION, SUBCELLULAR LOCATION, AND MASS
RP SPECTROMETRY.
RC TISSUE=Venom;
RA Zhu S.Y., Gao B.;
RT "Characterization of an antimicrobial peptide from the scorpion Mesobuthus
RT eupeus venom.";
RL Submitted (NOV-2009) to UniProtKB.
CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000269|Ref.2}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.2}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.2}.
CC -!- MASS SPECTROMETRY: Mass=5575; Method=MALDI;
CC Evidence={ECO:0000269|Ref.2};
CC -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC superfamily. Long chain multifunctional peptide (group 2) family.
CC {ECO:0000305}.
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DR EMBL; EF442050; ABR20115.1; -; mRNA.
DR AlphaFoldDB; P86407; -.
DR SMR; P86407; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Antimicrobial; Cleavage on pair of basic residues;
KW Direct protein sequencing; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000269|Ref.2"
FT CHAIN 23..71
FT /note="Meucin-49"
FT /evidence="ECO:0000269|Ref.2"
FT /id="PRO_0000401129"
SQ SEQUENCE 75 AA; 8685 MW; 644AF9DFE75DC6B2 CRC64;
MNKKILLVIF IVTMLIVDEV NSFKFGSFIK RMWRSKLAKK LRAKGKELLR DYANRVLSPE
EEAAAPAPVP AKRRR