ID   NDB2_TITDI              Reviewed;          77 AA.
AC   C9X4J0;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 18.
DE   RecName: Full=Bradykinin-potentiating peptide {ECO:0000303|PubMed:19470401};
DE            Short=BPP {ECO:0000303|PubMed:19470401};
DE            Short=TdBPP {ECO:0000303|PubMed:19470401};
DE   Flags: Precursor;
OS   Tityus discrepans (Venezuelan scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=57059;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19470401; DOI=10.1016/j.biochi.2009.05.005;
RA   D'Suze G., Schwartz E.F., Garcia-Gomez B.I., Sevcik C., Possani L.D.;
RT   "Molecular cloning and nucleotide sequence analysis of genes from a cDNA
RT   library of the scorpion Tityus discrepans.";
RL   Biochimie 91:1010-1019(2009).
CC   -!- FUNCTION: Antimicrobial peptide (By similarity). May also inhibit
CC       angiotensin-converting enzyme (ACE) and potentiate bradykinin (BK)
CC       (Probable). {ECO:0000250|UniProtKB:P86407,
CC       ECO:0000305|PubMed:19470401}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19470401}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:19470401}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Long chain multifunctional peptide (group 2) family.
CC       {ECO:0000305}.
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DR   EMBL; FN392268; CAY61908.1; -; mRNA.
DR   AlphaFoldDB; C9X4J0; -.
DR   SMR; C9X4J0; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antimicrobial; Cleavage on pair of basic residues; Hypotensive agent;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..73
FT                   /note="Bradykinin-potentiating peptide"
FT                   /id="PRO_5000525357"
FT   PROPEP          74..77
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000393387"
SQ   SEQUENCE   77 AA;  8731 MW;  008F02C24332867C CRC64;
     MNKKTLLVIF IVTLLIADEV NSFKFGGFLK KMWKSKLAKK LRAKGKQMLK EYANKVLSPE
     EEAPAAVPAG APERRRR