ID   NDB2_UROYA              Reviewed;          81 AA.
AC   L0GBQ6;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2013, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Antimicrobial peptide Con22;
DE   Flags: Precursor;
OS   Urodacus yaschenkoi (Inland robust scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Urodacinae; Urodacus.
OX   NCBI_TaxID=1273102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=23182832; DOI=10.1016/j.toxicon.2012.11.017;
RA   Luna-Ramirez K., Quintero-Hernandez V., Vargas-Jaimes L., Batista C.V.,
RA   Winkel K.D., Possani L.D.;
RT   "Characterization of the venom from the Australian scorpion Urodacus
RT   yaschenkoi: molecular mass analysis of components, cDNA sequences and
RT   peptides with antimicrobial activity.";
RL   Toxicon 63:44-54(2013).
CC   -!- FUNCTION: At high concentrations, acts as pore former in cellular
CC       membranes and causes the leakage of the cells. At submicromolar
CC       concentrations, degranulates granulocytes and has a weak hemolytic
CC       activity against human erythrocytes. Also strongly inhibits the
CC       production of superoxide anions. Has a strong antibacterial activity
CC       against Gram-negative bacteria but is less active against Gram-positive
CC       bacteria. Also has antifungal activity. {ECO:0000250|UniProtKB:P83313}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P83313}. Target
CC       cell membrane {ECO:0000250|UniProtKB:P83313}. Note=Forms a helical
CC       membrane channel in the prey. {ECO:0000250|UniProtKB:P83313}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:23182832}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Long chain multifunctional peptide (group 2) family.
CC       {ECO:0000305}.
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DR   EMBL; JX274243; AGA82757.1; -; mRNA.
DR   AlphaFoldDB; L0GBQ6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR012526; Antimicrobial_7.
DR   Pfam; PF08102; Antimicrobial_7; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cytolysis; Fungicide; Hemolysis; Ion transport;
KW   Membrane; Secreted; Signal; Target cell membrane; Target membrane;
KW   Transmembrane; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..65
FT                   /note="Antimicrobial peptide Con22"
FT                   /evidence="ECO:0000305|PubMed:23182832"
FT                   /id="PRO_5001091937"
FT   PROPEP          66..81
FT                   /evidence="ECO:0000250|UniProtKB:P83313"
FT                   /id="PRO_5001091938"
SQ   SEQUENCE   81 AA;  8929 MW;  94C035E7774449A8 CRC64;
     MNAKVMLVCL LVTMLVMEPA EAGIWSWIKK TAKKVWNSDV AKKLKGKALN VAKDFVAEKI
     GATPAEAGQI PFDEFMNVLY S