ID   NDB31_TITSE             Reviewed;          72 AA.
AC   A0A218QWY8;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   03-AUG-2022, entry version 6.
DE   RecName: Full=Hypotensin toxin Ts31 {ECO:0000303|PubMed:33181162};
DE   AltName: Full=Anti-hypertensive peptide {ECO:0000250|UniProtKB:P84189};
DE   AltName: Full=Tityustoxin-31 {ECO:0000305|PubMed:33181162};
DE   Flags: Precursor;
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887;
RN   [1] {ECO:0000312|EMBL:JAW07002.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Telson;
RX   PubMed=29561852; DOI=10.1371/journal.pone.0193739;
RA   de Oliveira U.C., Nishiyama M.Y. Jr., Dos Santos M.B.V.,
RA   Santos-da-Silva A.P., Chalkidis H.M., Souza-Imberg A., Candido D.M.,
RA   Yamanouye N., Dorce V.A.C., Junqueira-de-Azevedo I.L.M.;
RT   "Proteomic endorsed transcriptomic profiles of venom glands from Tityus
RT   obscurus and T. serrulatus scorpions.";
RL   PLoS ONE 13:e0193739-e0193739(2018).
RN   [2] {ECO:0000312|EMBL:QPD99058.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Telson;
RX   PubMed=33181162; DOI=10.1016/j.toxicon.2020.11.001;
RA   Kalapothakis Y., Miranda K., Pereira A.H., Witt A.S.A., Marani C.,
RA   Martins A.P., Leal H.G., Campos-Junior E., Pimenta A.M.C., Borges A.,
RA   Chavez-Olortegui C., Kalapothakis E.;
RT   "Novel components of Tityus serrulatus venom: a transcriptomic approach.";
RL   Toxicon 189:91-104(2021).
CC   -!- FUNCTION: Agonist of the B2 bradykinin receptor (BDKRB2). Potentiates
CC       the hypotensive effect of bradykinin (BK) and induces a direct
CC       vasorelaxing effect independent of BK, by endothelium- and nitric oxide
CC       (NO)-dependent mechanisms in rat aortic ring preparations. Also exerts
CC       proangiogenic, antiinflammatory, and antifibrogenic activities.
CC       {ECO:0000250|UniProtKB:P84189}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:29561852,
CC       ECO:0000305|PubMed:33181162}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:29561852, ECO:0000305|PubMed:33181162}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. {ECO:0000305}.
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DR   EMBL; GEUW01000043; JAW07002.1; -; mRNA.
DR   EMBL; MT450722; QPD99058.1; -; mRNA.
PE   3: Inferred from homology;
KW   Bradykinin receptor impairing toxin;
KW   G-protein coupled receptor impairing toxin; Hypotensive agent;
KW   Phosphoprotein; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..35
FT                   /evidence="ECO:0000250|UniProtKB:P84189"
FT                   /id="PRO_0000455734"
FT   PEPTIDE         36..60
FT                   /note="Hypotensin toxin Ts31"
FT                   /evidence="ECO:0000250|UniProtKB:P84189"
FT                   /id="PRO_5013301731"
FT   PROPEP          61..72
FT                   /evidence="ECO:0000250|UniProtKB:P84189"
FT                   /id="PRO_0000455735"
SQ   SEQUENCE   72 AA;  8033 MW;  9B743B06888E3FB4 CRC64;
     MKMMIAVFVS ILLLMFSLSS TAMGMETEQQ NMEERADVDF TGIADSIIKK IKETNAKPPA
     RFDPATFGEN ED