ID   NDB3S_OPICY             Reviewed;          80 AA.
AC   C5J897;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   03-AUG-2022, entry version 14.
DE   RecName: Full=Probable antimicrobial peptide clone Con10 {ECO:0000312|EMBL:CAX51401.1};
DE   Flags: Precursor;
OS   Opisthacanthus cayaporum (South American scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Hemiscorpiidae; Opisthacanthus.
OX   NCBI_TaxID=573324;
RN   [1] {ECO:0000312|EMBL:CAX51401.1, ECO:0000312|EMBL:CAX51402.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19379768; DOI=10.1016/j.toxicon.2009.04.010;
RA   Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P.,
RA   Possani L.D., Schwartz E.F.;
RT   "Cloning and characterization of cDNA sequences encoding for new venom
RT   peptides of the Brazilian scorpion Opisthacanthus cayaporum.";
RL   Toxicon 54:252-261(2009).
RN   [2]
RP   FUNCTION, AND SYNTHESIS OF 25-51.
RX   PubMed=27917162; DOI=10.3389/fmicb.2016.01844;
RA   Guilhelmelli F., Vilela N., Smidt K.S., de Oliveira M.A.,
RA   da Cunha Morales Alvares A., Rigonatto M.C., da Silva Costa P.H.,
RA   Tavares A.H., de Freitas S.M., Nicola A.M., Franco O.L., Derengowski L.D.,
RA   Schwartz E.F., Mortari M.R., Bocca A.L., Albuquerque P., Silva-Pereira I.;
RT   "Activity of scorpion venom-derived antifungal peptides against planktonic
RT   cells of Candida spp. and Cryptococcus neoformans and Candida albicans
RT   biofilms.";
RL   Front. Microbiol. 7:1844-1844(2016).
CC   -!- FUNCTION: Antimicrobial peptide (PubMed:27917162). Has antifungal
CC       activity against all strains tested with MICs values ranging from 12.5
CC       to 200 uM (PubMed:27917162). {ECO:0000269|PubMed:27917162}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:19379768}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:19379768}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Medium-length antimicrobial peptide (group 3) family.
CC       {ECO:0000305}.
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DR   EMBL; FM998756; CAX51401.1; -; mRNA.
DR   EMBL; FM998757; CAX51402.1; -; mRNA.
DR   AlphaFoldDB; C5J897; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antimicrobial; Cleavage on pair of basic residues; Fungicide; Secreted;
KW   Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         25..51
FT                   /note="Probable antimicrobial peptide clone Con10"
FT                   /evidence="ECO:0000305|PubMed:19379768"
FT                   /id="PRO_0000398606"
FT   PROPEP          56..80
FT                   /evidence="ECO:0000305|PubMed:19379768"
FT                   /id="PRO_0000398607"
SQ   SEQUENCE   80 AA;  9291 MW;  7E6E22CC91DF4681 CRC64;
     MQYKTKTFLV IFLAYLVVTN EAEAFWSFLV KAASKILPSL IGGGDDNKSS SKRKREIEDF
     FDPYQRELDL ELERLLSQLQ