ID   NDB3T_OPICY             Reviewed;          75 AA.
AC   C5J888;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=OcyC3 {ECO:0000303|PubMed:19379768};
DE   AltName: Full=Non-disulfide-bridged peptide 4.3 {ECO:0000303|PubMed:19379768};
DE            Short=NDBP-4.3 {ECO:0000303|PubMed:19379768};
DE   Flags: Precursor;
OS   Opisthacanthus cayaporum (South American scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Hemiscorpiidae; Opisthacanthus.
OX   NCBI_TaxID=573324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=19379768; DOI=10.1016/j.toxicon.2009.04.010;
RA   Silva E.C., Camargos T.S., Maranhao A.Q., Silva-Pereira I., Silva L.P.,
RA   Possani L.D., Schwartz E.F.;
RT   "Cloning and characterization of cDNA sequences encoding for new venom
RT   peptides of the Brazilian scorpion Opisthacanthus cayaporum.";
RL   Toxicon 54:252-261(2009).
RN   [2]
RP   MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=18502464; DOI=10.1016/j.toxicon.2008.03.029;
RA   Schwartz E.F., Camargos T.S., Zamudio F.Z., Silva L.P., Bloch C. Jr.,
RA   Caixeta F., Schwartz C.A., Possani L.D.;
RT   "Mass spectrometry analysis, amino acid sequence and biological activity of
RT   venom components from the Brazilian scorpion Opisthacanthus cayaporum.";
RL   Toxicon 51:1499-1508(2008).
CC   -!- FUNCTION: Amphipathic peptide with probable antimicrobial activity.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19379768}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2535.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:18502464};
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Medium-length antimicrobial peptide (group 3) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAX51392.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; FM998745; CAX51392.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; C5J888; -.
DR   SMR; C5J888; -.
DR   TCDB; 1.C.124.1.4; the antimicrobial pore-forming pandinin (pin) family.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   Antimicrobial; Cleavage on pair of basic residues; Secreted; Signal.
FT   SIGNAL          1..22
FT   PEPTIDE         23..46
FT                   /note="OcyC3"
FT                   /id="PRO_5000515181"
FT   PROPEP          51..75
FT                   /id="PRO_5000515182"
SQ   SEQUENCE   75 AA;  8590 MW;  72490B7D614D30E2 CRC64;
     MQYKTFLVIS LAYLLVADEA AAFWATLAKG ALKLIPTIAN AFSSKSKKRR EINNVFEPYH
     ENLDLELERF LSQLQ