NDB48_SCOTI
ID NDB48_SCOTI Reviewed; 74 AA.
AC P0DJO3;
DT 05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2012, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Amphipathic peptide CT1 {ECO:0000303|PubMed:19854232};
DE Short=StCT1 {ECO:0000303|PubMed:19854232};
DE AltName: Full=Non-disulfide-bridged peptide 4.8 {ECO:0000303|PubMed:24184590};
DE Short=NDBP-4.8 {ECO:0000303|PubMed:24184590};
DE AltName: Full=Non-disulfide-bridged peptide 5.16 {ECO:0000303|PubMed:23624072};
DE Short=NDBP-5.16 {ECO:0000303|PubMed:23624072};
DE Flags: Precursor;
OS Scorpiops tibetanus (Scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Iurida; Chactoidea; Euscorpiidae; Scorpiopinae; Scorpiopini;
OC Scorpiops.
OX NCBI_TaxID=500600;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AMIDATION AT VAL-37, AND FUNCTION.
RC TISSUE=Venom gland;
RX PubMed=19854232; DOI=10.1016/j.peptides.2009.10.008;
RA Yuan W., Cao L., Ma Y., Mao P., Wang W., Zhao R., Wu Y., Cao Z., Li W.;
RT "Cloning and functional characterization of a new antimicrobial peptide
RT gene StCT1 from the venom of the scorpion Scorpiops tibetanus.";
RL Peptides 31:22-26(2010).
RN [2]
RP NOMENCLATURE.
RX PubMed=23624072; DOI=10.1016/j.peptides.2013.03.026;
RA Zeng X.C., Zhou L., Shi W., Luo X., Zhang L., Nie Y., Wang J., Wu S.,
RA Cao B., Cao H.;
RT "Three new antimicrobial peptides from the scorpion Pandinus imperator.";
RL Peptides 45:28-34(2013).
RN [3]
RP NOMENCLATURE.
RX PubMed=24184590; DOI=10.1016/j.peptides.2013.10.021;
RA Almaaytah A., Albalas Q.;
RT "Scorpion venom peptides with no disulfide bridges: a review.";
RL Peptides 51:35-45(2014).
CC -!- FUNCTION: Antimicrobial peptide that is rapidly bactericidal against
CC Gram-positive bacteria (MIC=12.5 ug/ml against S.aureus, and MIC=100
CC ug/ml against M.luteus). Is also active against clinical antibiotics-
CC resistant bacterial strains. {ECO:0000269|PubMed:19854232}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC {ECO:0000250}. Note=Forms a helical membrane channel in the prey.
CC {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- MISCELLANEOUS: Is highly capable of inhibiting antibiotic-resistant
CC pathogen growth, including methicillin-resistant S.aureus. In vivo,
CC shows high antimicrobial activity on a S.aureus-infected mouse model
CC (PubMed:19854232). {ECO:0000305|PubMed:19854232}.
CC -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC superfamily. Short antimicrobial peptide (group 4) family.
CC {ECO:0000305}.
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DR EMBL; FD664386; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0DJO3; -.
DR SMR; P0DJO3; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW Cytolysis; Hemolysis; Membrane; Secreted; Signal; Target cell membrane;
KW Target membrane; Transmembrane.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PEPTIDE 24..37
FT /note="Amphipathic peptide CT1"
FT /id="PRO_0000418785"
FT PROPEP 41..74
FT /evidence="ECO:0000250"
FT /id="PRO_0000418786"
FT MOD_RES 37
FT /note="Valine amide"
FT /evidence="ECO:0000269|PubMed:19854232"
SQ SEQUENCE 74 AA; 8561 MW; B340C3D1E89DB002 CRC64;
MKTQIVILFI SMIMLQMFVQ IEGGFWGSLW EGVKSVVGKR GLRNLDDLDD LDLDHLFDSD
VSDADLRLLK QMFR
