NDB4S_CHATY
ID NDB4S_CHATY Reviewed; 91 AA.
AC P0DMF1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 11.
DE RecName: Full=Peptide Ctry2146 {ECO:0000303|PubMed:23415044};
DE Flags: Precursor;
OS Chaerilus tryznai (Scorpion).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC Scorpiones; Chaerilida; Chaeriloidea; Chaerilidae; Chaerilus.
OX NCBI_TaxID=1464547;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SYNTHESIS OF 24-33.
RC TISSUE=Venom gland;
RX PubMed=23415044; DOI=10.1016/j.biomaterials.2013.01.075;
RA Hong W., Zhang R., Di Z., He Y., Zhao Z., Hu J., Wu Y., Li W., Cao Z.;
RT "Design of histidine-rich peptides with enhanced bioavailability and
RT inhibitory activity against hepatitis C virus.";
RL Biomaterials 34:3511-3522(2013).
CC -!- FUNCTION: Antimicrobial peptide. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC {ECO:0000250}. Note=Forms an alpha-helical membrane channel in the
CC prey. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC -!- MISCELLANEOUS: Shows a low ability to inhibit hepatitis C virus (HCV)
CC infection in Huh7.5.1 cells. {ECO:0000305|PubMed:23415044}.
CC -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC superfamily. Short antimicrobial peptide (group 4) family.
CC {ECO:0000305}.
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DR AlphaFoldDB; P0DMF1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Amidation; Antimicrobial; Antiviral protein; Membrane; Secreted; Signal;
KW Target cell membrane; Target membrane.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PEPTIDE 24..33
FT /note="Peptide Ctry2146"
FT /id="PRO_0000428693"
FT PROPEP 37..91
FT /evidence="ECO:0000250"
FT /id="PRO_0000428694"
FT MOD_RES 33
FT /note="Leucine amide"
FT /evidence="ECO:0000250"
SQ SEQUENCE 91 AA; 9953 MW; B13564795B0E0778 CRC64;
MKTQTLLVTF LVVLLMVATQ TEAGIADILK GLLGKRGLLD GLLGKRGLLF GKRGPLFGKR
ALTNQDFLDF AYDPSLSAAD MDALEMLFED Y