ID   NDB4T_MESMA             Reviewed;          74 AA.
AC   Q2M591; A9NJI1;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 24.
DE   RecName: Full=Peptide BmKb2;
DE   AltName: Full=Small cationic antibacterial peptide Kb1;
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16040157; DOI=10.1016/j.peptides.2005.06.008;
RA   Luo F., Zeng X.-C., Hahin R., Cao Z.-J., Liu H., Li W.-X.;
RT   "Genomic organization of four novel nondisulfide-bridged peptides from
RT   scorpion Mesobuthus martensii Karsch: gaining insight into evolutionary
RT   mechanism.";
RL   Peptides 26:2427-2433(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=18023929; DOI=10.1016/j.peptides.2007.10.004;
RA   Gao B., Tian C., Zhu S.;
RT   "Inducible antibacterial response of scorpion venom gland.";
RL   Peptides 28:2299-2305(2007).
CC   -!- FUNCTION: Antibacterial peptide. This peptide gene is up-regulated at
CC       the transcriptional level after the venom gland is challenged by Gram-
CC       positive bacteria. {ECO:0000269|PubMed:18023929}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC       {ECO:0000250}. Note=Forms a helical membrane channel in the prey.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Short antimicrobial peptide (group 4) family.
CC       {ECO:0000305}.
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DR   EMBL; AY729077; AAW55473.1; -; Genomic_DNA.
DR   EMBL; EU158251; ABJ99487.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2M591; -.
DR   SMR; Q2M591; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Membrane; Secreted; Signal; Target cell membrane; Target membrane;
KW   Transmembrane.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         23..40
FT                   /note="Peptide BmKb2"
FT                   /id="PRO_0000231498"
FT   PROPEP          46..74
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000289970"
FT   MOD_RES         40
FT                   /note="Lysine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   74 AA;  8521 MW;  C863060F391D8B82 CRC64;
     MEIKYLLTVF LVLLIVSDHC QAFLSSLIPS AISGLISAFK GRRKRDLNGQ IDHFKNFRKR
     DAELEELLSK LPIY