ID   NDB4U_CHATY             Reviewed;          64 AA.
AC   P0DMF3;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Peptide Ctry2459 {ECO:0000303|PubMed:23415044};
DE   Flags: Precursor;
OS   Chaerilus tryznai (Scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Chaerilida; Chaeriloidea; Chaerilidae; Chaerilus.
OX   NCBI_TaxID=1464547;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 24-32, SUBCELLULAR LOCATION,
RP   CIRCULAR DICHROISM, AND MUTAGENESIS OF 29-LYS-ASN-30 AND GLY-26.
RC   TISSUE=Venom gland;
RX   PubMed=23415044; DOI=10.1016/j.biomaterials.2013.01.075;
RA   Hong W., Zhang R., Di Z., He Y., Zhao Z., Hu J., Wu Y., Li W., Cao Z.;
RT   "Design of histidine-rich peptides with enhanced bioavailability and
RT   inhibitory activity against hepatitis C virus.";
RL   Biomaterials 34:3511-3522(2013).
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23415044}.
CC       Note=Found in endosomes of the prey.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MISCELLANEOUS: inhibits hepatitis C virus (HCV) infection by
CC       inactivating infectious viral particles. However, it cannot suppress
CC       established infection because of the poor cellular uptake and
CC       restriction of endosomes (PubMed:23415044).
CC       {ECO:0000305|PubMed:23415044}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Short antimicrobial peptide (group 4) family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P0DMF3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Antimicrobial; Antiviral protein; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..32
FT                   /note="Peptide Ctry2459"
FT                   /id="PRO_0000428697"
FT   PROPEP          36..64
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000428698"
FT   MOD_RES         32
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   MUTAGEN         26
FT                   /note="G->H: Shows similar virucidal activities than the
FT                   wild-type, but enhances cellular uptake and improves
FT                   intracellular distribution; when associated with H-29-30-
FT                   H."
FT                   /evidence="ECO:0000269|PubMed:23415044"
FT   MUTAGEN         29..30
FT                   /note="KN->HH: Shows similar virucidal activities than the
FT                   wild-type, but enhances cellular uptake and improves
FT                   intracellular distribution; when associated with H-26.
FT                   Shows similar virucidal activities than the wild-type, but
FT                   enhances cellular uptake and improves intracellular
FT                   distribution."
FT                   /evidence="ECO:0000269|PubMed:23415044"
SQ   SEQUENCE   64 AA;  7437 MW;  CEA17EDEDDCAC5E1 CRC64;
     MKLQIILLIS AFILLLSISH TEAFLGFLKN LFGKRALRDL NKYDYMSDPS FSAEDIKALR
     ELFR