ID   NDB4U_MESMA             Reviewed;          70 AA.
AC   Q9GQW4;
DT   04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 36.
DE   RecName: Full=Peptide BmKn1 {ECO:0000303|PubMed:11463163};
DE   AltName: Full=Biologically active peptide 4;
DE   AltName: Full=Non-disulfide-bridged peptide 5.1 {ECO:0000303|PubMed:16036557};
DE            Short=NDBP-5.1 {ECO:0000303|PubMed:16036557};
DE   Flags: Precursor;
OS   Mesobuthus martensii (Manchurian scorpion) (Buthus martensii).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34649;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=11463163; DOI=10.1080/15216540120181;
RA   Zeng X.-C., Li W.-X., Wang S.-X., Zhu S.-Y., Luo F.;
RT   "Precursor of a novel scorpion venom peptide (BmKn1) with no disulfide
RT   bridge from Buthus martensii Karsch.";
RL   IUBMB Life 51:117-120(2001).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=16036557; DOI=10.1080/15216540500058899;
RA   Zeng X.C., Corzo G., Hahin R.;
RT   "Scorpion venom peptides without disulfide bridges.";
RL   IUBMB Life 57:13-21(2005).
CC   -!- FUNCTION: Antibacterial peptide. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC       {ECO:0000250}. Note=Forms an alpha-helical membrane channel in the
CC       prey. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Short antimicrobial peptide (group 4) family.
CC       {ECO:0000305}.
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DR   EMBL; AF151795; AAG39639.1; -; mRNA.
DR   EMBL; AF150010; AAK71696.1; -; mRNA.
DR   AlphaFoldDB; Q9GQW4; -.
DR   SMR; Q9GQW4; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Membrane; Secreted; Signal; Target cell membrane; Target membrane.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..36
FT                   /note="Peptide BmKn1"
FT                   /id="PRO_0000231499"
FT   PROPEP          40..70
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000289971"
FT   MOD_RES         36
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   70 AA;  7913 MW;  918A1A0E0E1D3860 CRC64;
     MKSQTFFLLF LVVLLLAISQ SEAFIGAVAG LLSKIFGKRS MRDMDTMKYL YDPSLSAADL
     KTLQKLMENY