ID   NDB4_BUTOS              Reviewed;          67 AA.
AC   B8XH50;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Amphipathic peptide Tx348 {ECO:0000303|Ref.1};
DE            Short=BoiTx348 {ECO:0000303|Ref.1};
DE   Flags: Precursor;
OS   Buthus occitanus israelis (Common yellow scorpion) (Buthus israelis).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Buthus.
OX   NCBI_TaxID=539894;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zilberberg N., Kozminsky-Atias A.;
RT   "Buthus occitanus israelis scorpion toxin.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Amphipathic peptide that has antibacterial activities.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC       {ECO:0000250}. Note=Forms an alpha-helical membrane channel in the
CC       prey. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Short antimicrobial peptide (group 4) family.
CC       {ECO:0000305}.
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DR   EMBL; FJ360839; ACJ23159.1; -; mRNA.
DR   AlphaFoldDB; B8XH50; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Membrane; Secreted; Signal; Target cell membrane; Target membrane;
KW   Transmembrane.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         24..33
FT                   /note="Amphipathic peptide Tx348"
FT                   /id="PRO_0000418795"
FT   PROPEP          37..67
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000418796"
FT   MOD_RES         33
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   67 AA;  7773 MW;  723AE59E77438D3D CRC64;
     MKSQAFFLLF LVVLLLATTQ SEAFIMDLLG KIFGRRSMRN MDTMKYLYDP SLSAADLKTL
     QKLMENY