ID   NDB4_HOTJU              Reviewed;          45 AA.
AC   F1CJ89;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Amphipathic peptide Hj0164 {ECO:0000303|PubMed:21329713};
DE   Flags: Precursor; Fragment;
OS   Hottentotta judaicus (Black scorpion) (Buthotus judaicus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Hottentotta.
OX   NCBI_TaxID=6863;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=21329713; DOI=10.1016/j.toxicon.2011.02.001;
RA   Morgenstern D., Rohde B.H., King G.F., Tal T., Sher D., Zlotkin E.;
RT   "The tale of a resting gland: transcriptome of a replete venom gland from
RT   the scorpion Hottentotta judaicus.";
RL   Toxicon 57:695-703(2011).
CC   -!- FUNCTION: Amphipathic peptide that shows antibacterial activities.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC       {ECO:0000250}. Note=Forms a helical membrane channel in the prey.
CC       {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Short antimicrobial peptide (group 4) family.
CC       {ECO:0000305}.
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DR   EMBL; HQ288198; ADY39620.1; -; mRNA.
DR   AlphaFoldDB; F1CJ89; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Cytolysis; Membrane; Secreted; Signal; Target cell membrane;
KW   Target membrane; Transmembrane.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         24..33
FT                   /note="Amphipathic peptide Hj0164"
FT                   /id="PRO_0000418789"
FT   PROPEP          37..>45
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000418790"
FT   MOD_RES         33
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000250"
FT   NON_TER         45
SQ   SEQUENCE   45 AA;  5049 MW;  4351A571FAEC2918 CRC64;
     MKSQAFFLLF LVVLLLATTQ SEAFLGALLS KIFGKRSLRD VDTMK