ID   NDB4_PANCV              Reviewed;          68 AA.
AC   H2CYR5;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Cytotoxic linear peptide;
DE   Flags: Precursor;
OS   Pandinus cavimanus (Tanzanian red clawed scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Iurida; Scorpionoidea; Scorpionidae; Pandininae; Pandinus.
OX   NCBI_TaxID=217261;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=22121013; DOI=10.1002/pmic.201100409;
RA   Diego-Garcia E., Peigneur S., Clynen E., Marien T., Czech L., Schoofs L.,
RA   Tytgat J.;
RT   "Molecular diversity of the telson and venom components from Pandinus
RT   cavimanus (Scorpionidae Latreille 1802): transcriptome, venomics and
RT   function.";
RL   Proteomics 12:313-328(2012).
CC   -!- FUNCTION: Amphipathic peptide that has antibacterial activities.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
CC       {ECO:0000250}. Note=Forms an alpha-helical membrane channel in the
CC       prey. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Short antimicrobial peptide (group 4) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; JN315745; AEX09223.1; -; mRNA.
DR   AlphaFoldDB; H2CYR5; -.
DR   SMR; H2CYR5; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amidation; Antibiotic; Antimicrobial; Cleavage on pair of basic residues;
KW   Membrane; Secreted; Signal; Target cell membrane; Target membrane;
KW   Transmembrane.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         24..36
FT                   /note="Cytotoxic linear peptide"
FT                   /id="PRO_0000418797"
FT   PROPEP          40..68
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000418798"
FT   SITE            29
FT                   /note="Important for activity"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         36
FT                   /note="Leucine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   68 AA;  7671 MW;  7C4D25C9748CC555 CRC64;
     MKTQFAILLI ALVLFQMFSQ SEAFLGGLWK AMSNLLGKRG LNELDDLDEL FDGEISQADI
     DFLKELMS