ID   NDB52_MESEU             Reviewed;          56 AA.
AC   P0CH58; E4VP33;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Meucin-25 {ECO:0000303|PubMed:20097251};
DE   AltName: Full=BeL-170 {ECO:0000303|PubMed:20097251};
DE   AltName: Full=Non-disulfide-bridged peptide 5.2 {ECO:0000303|PubMed:24184590};
DE            Short=NDBP-5.2 {ECO:0000303|PubMed:24184590};
DE   Flags: Precursor;
OS   Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus.
OX   NCBI_TaxID=34648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 32-56, AND FUNCTION.
RC   TISSUE=Venom gland;
RX   PubMed=20097251; DOI=10.1016/j.biochi.2010.01.011;
RA   Gao B., Xu J., Del Carmen Rodriguez M., Lanz-Mendoza H.,
RA   Hernandez-Rivas R., Du W., Zhu S.;
RT   "Characterization of two linear cationic antimalarial peptides in the
RT   scorpion Mesobuthus eupeus.";
RL   Biochimie 92:350-359(2010).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24184590; DOI=10.1016/j.peptides.2013.10.021;
RA   Almaaytah A., Albalas Q.;
RT   "Scorpion venom peptides with no disulfide bridges: a review.";
RL   Peptides 51:35-45(2014).
CC   -!- FUNCTION: This synthetic cationic peptide inhibits the development of
CC       Plasmodium berghei ookinetes, kills intraerythrocytic P.falciparum, and
CC       is cytotoxic to the Drosophila S2 cell at micromolar concentrations. No
CC       antibacterial, antifungal and hemolytic activities have been found at
CC       micromolar concentrations. {ECO:0000269|PubMed:20097251}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Antimalarial peptide (group 5) family. {ECO:0000305}.
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DR   EMBL; EF445075; ABR21050.1; -; mRNA.
DR   AlphaFoldDB; P0CH58; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         32..56
FT                   /note="Meucin-25"
FT                   /id="PRO_0000398383"
SQ   SEQUENCE   56 AA;  6764 MW;  64EBCEF836AFD7D3 CRC64;
     MFRIEYSLVQ LLLRNVTIPL LLIIQMHIMS SVKLIQIRIW IQYVTVLQMF SMKTKQ