ID   NDBP8_TITSE             Reviewed;           5 AA.
AC   C0HJT2;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2016, sequence version 1.
DT   23-FEB-2022, entry version 6.
DE   RecName: Full=Venom peptide 8 {ECO:0000303|PubMed:27221550};
OS   Tityus serrulatus (Brazilian scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=6887 {ECO:0000303|PubMed:27221550};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom {ECO:0000303|PubMed:27221550};
RX   PubMed=27221550; DOI=10.1016/j.peptides.2016.05.008;
RA   Pucca M.B., Cerni F.A., Pinheiro-Junior E.L., Zoccal K.F., Bordon K.C.,
RA   Amorim F.G., Peigneur S., Vriens K., Thevissen K., Cammue B.P.,
RA   Junior R.B., Arruda E., Faccioli L.H., Tytgat J., Arantes E.C.;
RT   "Non-disulfide-bridged peptides from Tityus serrulatus venom: Evidence for
RT   proline-free ACE-inhibitors.";
RL   Peptides 82:44-51(2016).
CC   -!- FUNCTION: Has a weak inhibitory effect on voltage-gated sodium channel
CC       Nav1.2/SCN2A. Weakly inhibits acetylcholine esterase in vitro.
CC       Increases interleukin-6 secretion from macrophages in vitro. Has no
CC       antifungal, antiviral or cytotoxic activity.
CC       {ECO:0000269|PubMed:27221550}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27221550}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:27221550}.
CC   -!- MISCELLANEOUS: No effect on voltage-gated potassium channels. No effect
CC       on voltage-gated sodium channels Nav1.3/SCN3A, Nav1.4/SCN4A,
CC       Nav1.5/SCN5A and a sodium channel from B.germanica.
CC       {ECO:0000269|PubMed:27221550}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0017080; F:sodium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Ion channel impairing toxin; Secreted; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   PEPTIDE         1..5
FT                   /note="Venom peptide 8"
FT                   /evidence="ECO:0000269|PubMed:27221550"
FT                   /id="PRO_0000438330"
SQ   SEQUENCE   5 AA;  689 MW;  75A4137053500000 CRC64;
     KIWRS