ID   NDBS_LYCMC              Reviewed;          86 AA.
AC   P0CI93;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   03-AUG-2022, entry version 20.
DE   RecName: Full=Bradykinin-potentiating peptide 25.12 {ECO:0000303|PubMed:20663230};
DE            Short=BPP-25.12 {ECO:0000303|PubMed:20663230};
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Yunnan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: Inhibits angiotensin-converting enzyme (ACE), but does not
CC       serve as substrate for the enzyme. Potentiates bradykinin (BK) on the
CC       isolated guinea pig ileum as well as the isolated rat uterus for
CC       contraction. Also potentiates in vivo the depressor effect of BK on
CC       arterial blood pressure in the normotensive anesthetized rat.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Long chain multifunctional peptide (group 2) family.
CC       {ECO:0000305}.
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DR   EMBL; GT028786; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0CI93; -.
DR   SMR; P0CI93; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hypotensive agent;
KW   Metalloenzyme inhibitor; Metalloprotease inhibitor; Protease inhibitor;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..81
FT                   /note="Bradykinin-potentiating peptide 25.12"
FT                   /id="PRO_0000403872"
FT   REGION          67..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   86 AA;  9885 MW;  6585EFC6285D6BBB CRC64;
     MNKRVLLVIF FVTLLIADEV NSFSFFRKAK GFLKKIWKSK IARRLREKGM KALKNYANDV
     INGPAEAPAA AAAPEEPPVE QRRRRR