ID   NDBW2_LYCMC             Reviewed;          62 AA.
AC   P0CI92;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=Ponericin-W-like 32.2;
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Yunnan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: Broad spectrum of activity against both Gram-positive and
CC       Gram-negative bacteria and S.cerevisiae. Has insecticidal and hemolytic
CC       activities. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Medium-length antimicrobial peptide (group 3) family.
CC       Ponericin-W subfamily. {ECO:0000305}.
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DR   EMBL; GT028820; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; P0CI92; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Cytolysis; Fungicide; Hemolysis; Secreted;
KW   Signal; Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         24..48
FT                   /note="Ponericin-W-like 32.2"
FT                   /id="PRO_0000403868"
FT   PROPEP          49..62
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403869"
SQ   SEQUENCE   62 AA;  7231 MW;  F3F39CAE431D64FA CRC64;
     MKCKKQLLVI FFAYFLVVNE SEAIFGSLFS LGSKLLPTVF KLFSRKKQRA LMKRDLEDIM
     DP