ID   NDB_TITME               Reviewed;          18 AA.
AC   P0DQU4;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 1.
DT   03-AUG-2022, entry version 2.
DE   RecName: Full=Probable bradykinin-potentiating peptide {ECO:0000303|PubMed:29337221};
DE            Short=BPP {ECO:0000305};
DE   AltName: Full=Probable antimicrobial peptide {ECO:0000250|UniProtKB:P86407};
OS   Tityus metuendus (Scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Tityus.
OX   NCBI_TaxID=2203750;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=29337221; DOI=10.1016/j.toxicon.2018.01.006;
RA   Batista C.V.F., Martins J.G., Restano-Cassulini R., Coronas F.I.V.,
RA   Zamudio F.Z., Procopio R., Possani L.D.;
RT   "Venom characterization of the Amazonian scorpion Tityus metuendus.";
RL   Toxicon 143:51-58(2018).
CC   -!- FUNCTION: Antimicrobial peptide (By similarity). May also inhibit
CC       angiotensin-converting enzyme (ACE) and potentiate bradykinin (BK) (By
CC       similarity). {ECO:0000250|UniProtKB:C9X4J0,
CC       ECO:0000250|UniProtKB:P86407}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29337221}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:29337221}.
CC   -!- MASS SPECTROMETRY: Mass=1735.00; Method=Electrospray; Note=Average
CC       mass.; Evidence={ECO:0000269|PubMed:29337221};
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Long chain multifunctional peptide (group 2) family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antimicrobial; Direct protein sequencing; Hypotensive agent; Secreted.
FT   PEPTIDE         1..18
FT                   /note="Probable bradykinin-potentiating peptide"
FT                   /id="PRO_0000455696"
SQ   SEQUENCE   18 AA;  1735 MW;  FED7C789862D9B46 CRC64;
     KVLAPAEEAP AEAPAAAE