ID   NDC1_CAEBR              Reviewed;         587 AA.
AC   Q60M68; A8Y4A5; H8WHD0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Nucleoporin ndc-1;
DE   AltName: Full=Nucleoporin npp-22;
GN   Name=npp-22; Synonyms=ndc-1;
GN   ORFNames=CBG29121 {ECO:0000312|WormBase:CBG29121};
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC       key role in de novo assembly and insertion of NPC in the nuclear
CC       envelope. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC       Nucleus membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Central core structure of the nuclear pore complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC1 family. {ECO:0000305}.
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DR   EMBL; HE601533; CCG58597.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q60M68; -.
DR   SMR; Q60M68; -.
DR   STRING; 6238.CBG29121; -.
DR   EnsemblMetazoa; CBG29121.1; CBG29121.1; WBGene00219320.
DR   WormBase; CBG29121; CBP37908; WBGene00219320; Cbr-npp-22.
DR   eggNOG; KOG3726; Eukaryota.
DR   eggNOG; KOG4358; Eukaryota.
DR   HOGENOM; CLU_464804_0_0_1; -.
DR   InParanoid; Q60M68; -.
DR   OMA; VVQKDLH; -.
DR   Proteomes; UP000008549; Chromosome V.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070762; C:nuclear pore transmembrane ring; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR   PANTHER; PTHR13269; PTHR13269; 1.
DR   Pfam; PF09531; Ndc1_Nup; 1.
PE   3: Inferred from homology;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..587
FT                   /note="Nucleoporin ndc-1"
FT                   /id="PRO_0000235246"
FT   TOPO_DOM        1..79
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        80..100
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        101..121
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        122..142
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        143..161
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..187
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        209..255
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        277..281
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        303..587
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          32..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   587 AA;  66206 MW;  A3B993E3B7B50CAD CRC64;
     MMGENSSAYT TLADNQLYNQ FSPSRRKADL IASTSATSSP NLRKSPNRGF SSPRAQQKPI
     TIFDQIVSWF HSEIDVRKKL ASFVCGAAVA LSFIVTVSIL KLSIWAPFSS VQDSLTWWLY
     PTSWPVTLFI WLSSVAWTFL IIHQFCTVTQ VPRIPITDTY AWAGAALEFV HRLIFVYTAF
     TVSESSFFED FAWIAIAFSV AISSALVIFR SDFHLNFSNV QVNSFKTLID FAKSLPYGSL
     AETSGVDAAI AYTAAMALTV FGSPLLWGFS AWWLLINIQF HLVLFGVCFA QQFFAKIFMK
     IVNQIVMKPM KFPFPPPYTV HSPTPDQIRT LPNVIETDDP LLKMFALHDL RTVAWEDEKR
     RVDVFSLSQP GKHPRNWKAV SMPCTRMLDE LCSRMTVSAA RLVGYSWDDH DVENEEVPRD
     ALMMPRKMRE MTYRGAGQSR QQKTIAPIRS NNTQTVGFLA KITRNLGLGK TERLVISRFD
     AQQNAYAAEA VYMLVVDSMG EDRFGVVQKD LKDLITLLCK LIAAIDTYER AKASVADKSD
     VTYLRLVDAS LKSCLQRVVT TFGSHLRSLE LADEHIRTIK LVCAEEI