NDC1_CAEEL
ID NDC1_CAEEL Reviewed; 588 AA.
AC Q8I4N3;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Nucleoporin ndc-1;
DE AltName: Full=Nucleoporin npp-22;
GN Name=npp-22; Synonyms=ndc-1; ORFNames=B0240.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC key role in de novo assembly and insertion of NPC in the nuclear
CC envelope. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC Nucleus membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Central core structure of the nuclear pore complex.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NDC1 family. {ECO:0000305}.
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DR EMBL; Z74026; CAD54122.1; -; Genomic_DNA.
DR RefSeq; NP_505962.2; NM_073561.5.
DR AlphaFoldDB; Q8I4N3; -.
DR SMR; Q8I4N3; -.
DR BioGRID; 44632; 2.
DR IntAct; Q8I4N3; 1.
DR STRING; 6239.B0240.4; -.
DR EPD; Q8I4N3; -.
DR PaxDb; Q8I4N3; -.
DR PeptideAtlas; Q8I4N3; -.
DR PRIDE; Q8I4N3; -.
DR EnsemblMetazoa; B0240.4.1; B0240.4.1; WBGene00007118.
DR GeneID; 179607; -.
DR KEGG; cel:CELE_B0240.4; -.
DR UCSC; B0240.4.1; c. elegans.
DR CTD; 179607; -.
DR WormBase; B0240.4; CE31866; WBGene00007118; npp-22.
DR eggNOG; KOG3726; Eukaryota.
DR eggNOG; KOG4358; Eukaryota.
DR GeneTree; ENSGT00390000014590; -.
DR HOGENOM; CLU_464804_0_0_1; -.
DR InParanoid; Q8I4N3; -.
DR OMA; VVQKDLH; -.
DR OrthoDB; 556184at2759; -.
DR PhylomeDB; Q8I4N3; -.
DR Reactome; R-CEL-159227; Transport of the SLBP independent Mature mRNA.
DR Reactome; R-CEL-159230; Transport of the SLBP Dependant Mature mRNA.
DR Reactome; R-CEL-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR Reactome; R-CEL-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR Reactome; R-CEL-191859; snRNP Assembly.
DR Reactome; R-CEL-3108214; SUMOylation of DNA damage response and repair proteins.
DR Reactome; R-CEL-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR Reactome; R-CEL-3371453; Regulation of HSF1-mediated heat shock response.
DR Reactome; R-CEL-4085377; SUMOylation of SUMOylation proteins.
DR Reactome; R-CEL-4551638; SUMOylation of chromatin organization proteins.
DR PRO; PR:Q8I4N3; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00007118; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IDA:WormBase.
DR GO; GO:0070762; C:nuclear pore transmembrane ring; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR PANTHER; PTHR13269; PTHR13269; 1.
DR Pfam; PF09531; Ndc1_Nup; 2.
PE 3: Inferred from homology;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..588
FT /note="Nucleoporin ndc-1"
FT /id="PRO_0000235247"
FT TOPO_DOM 1..79
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..122
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..190
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..588
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 588 AA; 65763 MW; 4B12FC3B9D4D3203 CRC64;
MMGDSHSSFT TTTDEHLYNQ FSPGRRKNDF PAASSSSSSP NLRRSPNRTV SSPRVQQKPI
TIFDQIVDWF QAEISVRKRL AGAACGYLST IFFIVTVSIL KLTIWAPFSS VQDSLAWWIY
PNAWASIIFV GIASVAMSLF SIIKFCKVDQ LPRLAATDTF ALAGVALEFV TRLTFVYTAF
CVADFSFSRE FAFVAISLAI AISSALVVFR SDYQLNFSHI QVNSVKTLID FGTSLPYANI
SEICGIDAAI SYTAAVALIL VVGPMVSGFS AWWLLLNIPF HVVLFGLCFT QQFYSKISMK
IVNQIVMKPI SFPFPPPYTV HSPTPEQTRT LPNVIETDDS LLKFFALHDL RTIAWNDEKR
RVDVFSLSQP GKHPRNWKAV SLPCVRMLDE LCSRMTVSAA RLVGYSWDDH DIENEDVPRD
ALLMPRKMRE MAYRGTGQSR QQKSMAPIRS HNTQTVGLLS KISNFLGFGV TEKLVISRFD
AHMNAYAAEA LYMLVVDSMG EDRFGVVQKD LKDLITLLCK LIAAIDTYER AKASVADKSD
VTFLRIVDAS LKSSLQRVVT TFGSHLSSLN LPEEHSRTIR MICLTDEL
