ID   NDC1_DANRE              Reviewed;         671 AA.
AC   Q7SZC5;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Nucleoporin NDC1;
DE   AltName: Full=Transmembrane protein 48;
GN   Name=ndc1; Synonyms=tmem48; ORFNames=zgc:55636;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC       key role in de novo assembly and insertion of NPC in the nuclear
CC       envelope. Required for NPC and nuclear envelope assembly, possibly by
CC       forming a link between the nuclear envelope membrane and soluble
CC       nucleoporins, thereby anchoring the NPC in the membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC       Nucleus membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Central core structure of the nuclear pore complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC1 family. {ECO:0000305}.
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DR   EMBL; BC053915; AAH53915.1; -; mRNA.
DR   RefSeq; NP_956237.1; NM_199943.1.
DR   AlphaFoldDB; Q7SZC5; -.
DR   SMR; Q7SZC5; -.
DR   STRING; 7955.ENSDARP00000016349; -.
DR   PaxDb; Q7SZC5; -.
DR   GeneID; 335236; -.
DR   KEGG; dre:335236; -.
DR   CTD; 55706; -.
DR   ZFIN; ZDB-GENE-030131-7176; ndc1.
DR   eggNOG; KOG4358; Eukaryota.
DR   InParanoid; Q7SZC5; -.
DR   OrthoDB; 556184at2759; -.
DR   PhylomeDB; Q7SZC5; -.
DR   Reactome; R-DRE-159227; Transport of the SLBP independent Mature mRNA.
DR   Reactome; R-DRE-159230; Transport of the SLBP Dependant Mature mRNA.
DR   Reactome; R-DRE-159231; Transport of Mature mRNA Derived from an Intronless Transcript.
DR   Reactome; R-DRE-159236; Transport of Mature mRNA derived from an Intron-Containing Transcript.
DR   Reactome; R-DRE-191859; snRNP Assembly.
DR   Reactome; R-DRE-3108214; SUMOylation of DNA damage response and repair proteins.
DR   Reactome; R-DRE-3232142; SUMOylation of ubiquitinylation proteins.
DR   Reactome; R-DRE-3301854; Nuclear Pore Complex (NPC) Disassembly.
DR   Reactome; R-DRE-3371453; Regulation of HSF1-mediated heat shock response.
DR   Reactome; R-DRE-4085377; SUMOylation of SUMOylation proteins.
DR   Reactome; R-DRE-4551638; SUMOylation of chromatin organization proteins.
DR   Reactome; R-DRE-4570464; SUMOylation of RNA binding proteins.
DR   Reactome; R-DRE-4615885; SUMOylation of DNA replication proteins.
DR   Reactome; R-DRE-5578749; Transcriptional regulation by small RNAs.
DR   Reactome; R-DRE-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR   PRO; PR:Q7SZC5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070762; C:nuclear pore transmembrane ring; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0006999; P:nuclear pore organization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR   PANTHER; PTHR13269; PTHR13269; 1.
DR   Pfam; PF09531; Ndc1_Nup; 1.
PE   2: Evidence at transcript level;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW   Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..671
FT                   /note="Nucleoporin NDC1"
FT                   /id="PRO_0000235244"
FT   TOPO_DOM        1..19
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        20..40
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        41..64
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..109
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..156
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        178..220
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        242..260
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        261..281
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        282..671
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          378..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          480..508
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..405
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        483..497
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   671 AA;  74441 MW;  B8097A8F69E07BE7 CRC64;
     MFSMKQNCWF IRKVVIWRAV ASIAWSVLLL PITTAVFVLL SRFSLFHPIQ WISDCTNLLT
     ASSTIFSLMV LCAVVLITGF FNLEFYTLVP SIPCSRVALL GTVLHPLQCV HSLVYSSMGM
     LVMWCASVII SGRYSTLGTP CMQNESGDVL TCLNEYHLFL LLAGAFMGYS HSFLGVVKNM
     YYVSFQPIQQ YKYPQFKGCL PMLLKCSVIQ SLYSTRNFAA LYFFFGYVPR AWISSTLNLP
     IDSSLQPLDS LTGLLDFSLL YHLSISGTFL YFTWYLTVLI FRIYATEAYS FPVQSTFSED
     AERCLPKVVG EKSTLVMKFL ALQDLALLSQ HSPSRRQEVF SLSQPGGHPH NWNAISGECL
     CLLRDLTQRL VAHQDAVASN GRVKSQSASS DTRSASSSSS VLSGMEDVPE TPRPTVPLRT
     PGSVFKSSVG GMHSSLTAPF TPDVDSPFCS PAIRRLVGQQ DPQSPWFGTV QSPHIMRRGP
     KLWSASTESQ SNGSPPASPA IAPSPPAANK KPSFLAQWLQ NRKEQVKSFL AKRVLIVYLF
     NKLPEASSQA LFADSQAHIW ALQGLSHLVA ASFSEDQFGV VQTTLPSILS SLVVLLEAVD
     RHFKLPHASS KPARTVCSMG DSTYKTLRFA LRAALKTAIY KITTTFGEHL NAVNISTEHR
     KRLQQFLEFK E