NDC1_DROPS
ID NDC1_DROPS Reviewed; 579 AA.
AC Q298S5;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Nucleoporin Ndc1;
GN Name=Ndc1; ORFNames=GA19183;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC key role in de novo assembly and insertion of NPC in the nuclear
CC envelope. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC Nucleus membrane {ECO:0000250}; Multi-pass membrane protein
CC {ECO:0000250}. Note=Central core structure of the nuclear pore complex.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NDC1 family. {ECO:0000305}.
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DR EMBL; CM000070; EAL27880.1; -; Genomic_DNA.
DR RefSeq; XP_001358737.1; XM_001358700.4.
DR AlphaFoldDB; Q298S5; -.
DR SMR; Q298S5; -.
DR STRING; 7237.FBpp0282051; -.
DR EnsemblMetazoa; FBtr0283613; FBpp0282051; FBgn0079180.
DR GeneID; 4801689; -.
DR KEGG; dpo:Dpse_GA19183; -.
DR eggNOG; KOG4358; Eukaryota.
DR HOGENOM; CLU_027343_0_0_1; -.
DR InParanoid; Q298S5; -.
DR OMA; MIYSWIQ; -.
DR PhylomeDB; Q298S5; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0079180; Expressed in female reproductive system and 2 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR PANTHER; PTHR13269; PTHR13269; 1.
DR Pfam; PF09531; Ndc1_Nup; 1.
PE 3: Inferred from homology;
KW Membrane; mRNA transport; Nuclear pore complex; Nucleus; Protein transport;
KW Reference proteome; Translocation; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..579
FT /note="Nucleoporin Ndc1"
FT /id="PRO_0000235249"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..42
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 43..60
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 61..81
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 82..106
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 128..144
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..202
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 224..236
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 258..579
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 579 AA; 65979 MW; E24D745F457D119C CRC64;
MSHLSTINAC KLLLFRRCLQ AVLLTVGIQF LLLTIFLLFV NFQLLRPLHW ISVTLSLVCS
MYTWFASIPL VGAVVLYGMI LCQQHLAERL YCPTRFRWLV HYAPRKLLFL AAHLLVGYLT
AWLYTGYMHT DYRHLWYKCY DQECISAYHV YLLGMGIFAG CYYFVSVHMR QEVEIEFPIV
NHLWGEKLRE VLYSSLARSL IKSLLPTLAY TLLFWLFGGV VCHKLSHIFA VDLDERLEGF
FGVATNGRLL FYGWLLTSQI LSNMHLMRCF YSMFLSEEFP LAITKNRAAF VQEKEVTVVA
ALGLSNVYVV QCLAAKYLYN LVTAGDAEKR SELFQLTEPG NRPANWRSLC DQCLSLFGNF
TDELIDSMQK ISVLKGSPSS PPLTPISENA SASLMAERVL TRQYNQMHGI RAIVSPRSNA
VIDRPVDRIH RVPDWCERTS MQLEQSLQLL INRIPGIVYM FTEPEGAKTA FLLTHSLPLV
FVIQALSQIC VFSLKEDRYG VVQTDLPDII RSMSRLKGEL DKLSSVASNL RGPGSSFSVL
RGAVRRSLFH ICVAFGEYLS ELIPSGEELH QLQTVINQE
