ID   NDC1_PONAB              Reviewed;         674 AA.
AC   Q5RBY5;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Nucleoporin NDC1;
DE   AltName: Full=Transmembrane protein 48;
GN   Name=NDC1; Synonyms=TMEM48;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC       key role in de novo assembly and insertion of NPC in the nuclear
CC       envelope. Required for NPC and nuclear envelope assembly, possibly by
CC       forming a link between the nuclear envelope membrane and soluble
CC       nucleoporins, thereby anchoring the NPC in the membrane (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the NUP35/NUP53.
CC       {ECO:0000250|UniProtKB:Q6AXN4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000250}.
CC       Nucleus membrane {ECO:0000250}; Multi-pass membrane protein
CC       {ECO:0000250}. Note=Central core structure of the nuclear pore complex.
CC       {ECO:0000250}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC1 family. {ECO:0000305}.
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DR   EMBL; CR858497; CAH90725.1; -; mRNA.
DR   RefSeq; NP_001125404.1; NM_001131932.1.
DR   AlphaFoldDB; Q5RBY5; -.
DR   STRING; 9601.ENSPPYP00000001548; -.
DR   GeneID; 100172309; -.
DR   KEGG; pon:100172309; -.
DR   CTD; 55706; -.
DR   eggNOG; KOG4358; Eukaryota.
DR   InParanoid; Q5RBY5; -.
DR   OrthoDB; 556184at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR   GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR   PANTHER; PTHR13269; PTHR13269; 1.
DR   Pfam; PF09531; Ndc1_Nup; 1.
PE   2: Evidence at transcript level;
KW   Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein;
KW   Protein transport; Reference proteome; Translocation; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..674
FT                   /note="Nucleoporin NDC1"
FT                   /id="PRO_0000235242"
FT   TOPO_DOM        1..24
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..68
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..165
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        187..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        226..246
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        247..272
FT                   /note="Perinuclear space"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..674
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          394..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..419
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         406
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
FT   MOD_RES         414
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
FT   MOD_RES         439
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
FT   MOD_RES         440
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
FT   MOD_RES         445
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
FT   MOD_RES         449
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
FT   MOD_RES         471
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
FT   MOD_RES         474
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BTX1"
SQ   SEQUENCE   674 AA;  76078 MW;  21A3796EF0BF611F CRC64;
     MATAVSGPCA GRSRDILWRV LGWRIVASII WSVLLLPICT TVFIIFSRID LFHPIQWLSD
     SFSDLYSSYV IFYLLLLSVV IIIISIFNVE FYAVVPSIPC SRLALIGKII HPQQLMHSFI
     HAAMGMVMAW CAAVITQGQY SFLVVPCTGA NSFGSPAAQT CLNEYHLFFL LAGALMGYSY
     SLLYFVNNMN YLPFPIIQQY KFLRFRRSLL LLVKHSCVES LFLVRNFCIL YYFLGYIPKA
     WISTAMNLHI DEQVHRPLDT VSGLLNLSLL YHVWLCGAFL LTTWYVSWIL FKIYATEAHV
     FPVQPPFAEG SDECLPKVLN SNPPPIIKYL ALQDLMLFSQ YSPSRRQEVF SLSQPGGHPH
     NWTAISRECL NLLNGMTQKL VLYQEAAATN GRVSSSYPVE PKKLNSPEET TFQTPKSSQM
     PRPSVPPLVK TSLFSSKLST PEVVSPFGTP FGSSVMNRMA GIFDVNTCFG SPQSPQLIRR
     GPRLWTSASD QQMTEFSNPS PSTSISAEGK TMRQPSVIYS WIQNKREQIK NFLSKRVLIM
     YFFSKHPEAS IQAVFSDAQM HIWALEGLSH LVAASFTEDR FGVVQTTLPA ILNTLLTLQE
     AVDKYFKLPH ASSKPPRISG SLVDTSYKTL RFAFRASLKT AIYRITTTFG EHLNAVQASA
     EHQKRLQQFL EFKE