NDC1_XENLA
ID NDC1_XENLA Reviewed; 660 AA.
AC Q6AX31;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Nucleoporin NDC1;
DE Short=xNDC1;
DE AltName: Full=Transmembrane protein 48;
GN Name=ndc1; Synonyms=tmem48;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16702233; DOI=10.1083/jcb.200601001;
RA Stavru F., Hulsmann B.B., Spang A., Hartmann E., Cordes V.C., Gorlich D.;
RT "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore
RT complexes.";
RL J. Cell Biol. 173:509-519(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=16600873; DOI=10.1016/j.molcel.2006.02.015;
RA Mansfeld J., Guettinger S., Hawryluk-Gara L.A., Pante N., Mall M., Galy V.,
RA Haselmann U., Muehlhaeusser P., Wozniak R.W., Mattaj I.W., Kutay U.,
RA Antonin W.;
RT "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore
RT complex assembly in vertebrate cells.";
RL Mol. Cell 22:93-103(2006).
CC -!- FUNCTION: Component of the nuclear pore complex (NPC), which plays a
CC key role in de novo assembly and insertion of NPC in the nuclear
CC envelope. Required for NPC and nuclear envelope assembly, possibly by
CC forming a link between the nuclear envelope membrane and soluble
CC nucleoporins, thereby anchoring the NPC in the membrane.
CC {ECO:0000269|PubMed:16600873}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000269|PubMed:16600873}. Nucleus membrane
CC {ECO:0000269|PubMed:16600873}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:16600873}. Note=Central core structure of the
CC nuclear pore complex.
CC -!- SIMILARITY: Belongs to the NDC1 family. {ECO:0000305}.
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DR EMBL; DQ191159; ABA39292.1; -; mRNA.
DR EMBL; BC079784; AAH79784.1; -; mRNA.
DR RefSeq; NP_001087436.1; NM_001093967.2.
DR PDB; 7WKK; EM; 4.20 A; N/n=1-660.
DR PDBsum; 7WKK; -.
DR AlphaFoldDB; Q6AX31; -.
DR DNASU; 447260; -.
DR GeneID; 447260; -.
DR KEGG; xla:447260; -.
DR CTD; 447260; -.
DR Xenbase; XB-GENE-5736383; ndc1.S.
DR OMA; FGPLICH; -.
DR OrthoDB; 556184at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 447260; Expressed in egg cell and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR019049; Nucleoporin_prot_Ndc1/Nup.
DR PANTHER; PTHR13269; PTHR13269; 1.
DR Pfam; PF09531; Ndc1_Nup; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Membrane; mRNA transport; Nuclear pore complex; Nucleus;
KW Protein transport; Reference proteome; Translocation; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..660
FT /note="Nucleoporin NDC1"
FT /id="PRO_0000235245"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..57
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..103
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 104..124
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 125..154
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..175
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 176..205
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 227..256
FT /note="Perinuclear space"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 278..660
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 375..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 660 AA; 74338 MW; 416AAF43AFBAD952 CRC64;
MTMLGERLVL RWRVAASFAW SVILMPVCCA LFIVLSRIQI LHPIQWLTDS ISDLTSSYTI
FCLLLICAIL GLQCTFLMEY YTVVPSIPCS RLALIGNLLL PHRILHSLAH VAMGVLASWC
YAVLSKGKYQ LLVVSCTLQS EDEADKPSHC LNESHLFQLL CGAFFGYSYS LQYFVHNMNY
LSFPSIQQYK YLQFRRFLPL IIKQSVFQSL YFIRSYAILY FCLGNIPRTW IQTALNLHMD
RQQPSLDTLR GFLNLSLFYQ IWLSGTFLLA TWYMVWILFR IYTTEARIFP VQTSFAEEAE
KCLPFILNSN TLPLVKYLAM QDLVLLSQYS PSRRQEVFSL SQPGGHPHNW TSISKECLNL
MSSLTSRLIA HQEAAANNGR MRVPSSPKQI RKSSSSSGTS LIEDSAEQTQ NLSTIPRIGI
PSLLKTASLK SSLDIGSPFA TPGVKQMSES LDPNTPCHGS VQSPQVTRRG AKLWTSDSDV
QKNGSEVSPV MHRPVCNGAK QGILHTWFQH KLVQIKNVLS KRGLIMYLFS KHPEASSQDV
FADAQIHIWA LEALSHLVAA SFSEDRMGVV QTSLSSVLAI LLTLQEAVEK HFKLPHASSK
PARNPGSLLD SSCKTLRFSL RAALKTAIYR ITTTFGEHLH AVPVSSEHKK KLQQFLDFKE
