ID   NDC80_ASHGO             Reviewed;         661 AA.
AC   Q753N1;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Probable kinetochore protein NDC80;
GN   Name=NDC80; OrderedLocusNames=AFR281C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 169-172; 179-180 AND 536-544.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016819; AAS53652.2; -; Genomic_DNA.
DR   RefSeq; NP_985828.2; NM_211183.2.
DR   AlphaFoldDB; Q753N1; -.
DR   SMR; Q753N1; -.
DR   STRING; 33169.AAS53652; -.
DR   PRIDE; Q753N1; -.
DR   EnsemblFungi; AAS53652; AAS53652; AGOS_AFR281C.
DR   GeneID; 4622091; -.
DR   KEGG; ago:AGOS_AFR281C; -.
DR   eggNOG; KOG0995; Eukaryota.
DR   HOGENOM; CLU_012583_1_2_1; -.
DR   InParanoid; Q753N1; -.
DR   OMA; IRFKVHV; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0008017; F:microtubule binding; IEA:EnsemblFungi.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblFungi.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR040967; DUF5595.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF18077; DUF5595; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..661
FT                   /note="Probable kinetochore protein NDC80"
FT                   /id="PRO_0000246631"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          54..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          368..398
FT                   /evidence="ECO:0000255"
FT   COILED          507..623
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        9..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  75839 MW;  0ED98A17E488BE88 CRC64;
     MAERRGSSGA NGVLNSLNPQ RFTSQIPSIG GNTNKKGVPG TNAALTDMIN KSLARNGRSS
     LSRPVPEVRK SLRRSLRSSQ RPSIVPGGGP SAYGALQSTR DPRPLRDKNY QAVLQQEIFD
     YLQSRKFDIE TGHAISLKSL KQPTQKDFIC IFRWLYRRLD PGYSFKRSLE TEVYSILKTI
     QYPFLDTINK SQISAVGGSN WHKFLGMLHW LMNTSQRLDS CLHKLDESKT MQLTQDITIL
     NQPVTTLDEQ DEKHEQYELM VERLFIEYIS KCYKSFINME DDFSPFKEEL EIGFDRFVHI
     IETDINNLGR QEEMLQQDCE MFAARCEGLK LARSKHQALK GDLVKFQNYI NAMKNKAEDW
     PRKLNQMVEE INEKKGLIKD IHAEIDKLRQ ALSQEDIQEI DQMNQQRDTF SKMLDTVSSK
     LDNLTGSVKS QKLNLESSSK VFLDTLEKFN ASINGFVLAR NNLQHPINPA ELLIPVKANI
     TLTDSTAITP STILEGCTDI LSSIKPNLLK VNKEIDERIS ALQTENNQLE KELRGLRDTI
     TSKGHMLESM ENELSNIKSE YDEYQQVSHS KLLSQRIEIE KLERKIQNDR HKTQQRVAQA
     EQEIEDAAFK LKELTLKIQQ ERVVLHRKLI KVIEYVVSFK MDVQGSIEAL HDFSVEQLES
     L