ID   NDC80_ASPFU             Reviewed;         736 AA.
AC   Q4WXP0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Probable kinetochore protein ndc80;
GN   Name=ndc80; ORFNames=AFUA_3G10180;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC       ndc80, nuf2 and spc24. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL92563.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AAHF01000002; EAL92563.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_754601.1; XM_749508.1.
DR   AlphaFoldDB; Q4WXP0; -.
DR   SMR; Q4WXP0; -.
DR   STRING; 746128.CADAFUBP00003817; -.
DR   PRIDE; Q4WXP0; -.
DR   GeneID; 3511788; -.
DR   KEGG; afm:AFUA_3G10180; -.
DR   eggNOG; KOG0995; Eukaryota.
DR   HOGENOM; CLU_012583_0_0_1; -.
DR   InParanoid; Q4WXP0; -.
DR   OrthoDB; 925552at2759; -.
DR   Proteomes; UP000002530; Chromosome 3.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..736
FT                   /note="Probable kinetochore protein ndc80"
FT                   /id="PRO_0000246632"
FT   REGION          57..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          327..492
FT                   /evidence="ECO:0000255"
FT   COILED          586..690
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        57..74
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..127
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   736 AA;  83995 MW;  C36E1C980A7D1EC9 CRC64;
     MRSDGLRLTN IFLIQTLGSV QNYSALPQPS SALKRTSSIG YQNPPFTSQH TRSMSLLNSA
     SRPQQPNFQR SSSGGAFGAD AGLSSVRRSV SSNIFHGASV GRPSYAPGSL SASSASQSLQ
     RRSSVFSRPS VGGPMGHQSF FTQVPNAAGV PRDPRPLRDR SFQARIGQEL LEYLTHNNFE
     LEMKHSLGQN TLRSPTQKDF NYIFQFLYHR IDPGYRFQKS MDAEVPPILK QLRYPFEKGI
     TKSQIAAVGG QNWPTFLGML HWLMQLAQMM DRFVLGEYDE ACAEMGVDVS GDRIIFRFLT
     GAYHDWLQGG EDEDDETAEK RLVPHIESMA QEFERGNEKY MQEMQVLEAE NRALRDQIEE
     LEKNAPDMAK LDKHFRILED DKRKFEDYNQ NVQGKIEKYE NRIKFLEEEI QKVEAELQAA
     EEERSSLQSS VDQQGITIQD IDRMNTERDR LQKSLEDTTA RLEETHARVM EKEAEASRKL
     EDLEEIVKVY NTLGYQTSLI PSTAVNAKGQ DYELSLNIND NSFSASQIGG LPNRISSEAD
     RLLAEPFTGY HPAHLLNLDL RGMVRSSLQA LRKEINERRK RAIDDDLERR NLLDNIKEAM
     DEKRSEVEAL EHKRRAAEEE FERLKEITTT QKLASDAQIE KMEKELAKMR ATLSESVQLM
     EQREMNTNIE YEQLTLRANA LREELHTNVE SMLNDVIRFK VHIQKGLEDY ESFVVDEVEQ
     ELGGDLPATK DVTSQT