ID   NDC80_ASPOR             Reviewed;         736 AA.
AC   Q2UL45;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Probable kinetochore protein ndc80;
GN   Name=ndc80; ORFNames=AO090003000554;
OS   Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=510516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 42149 / RIB 40;
RX   PubMed=16372010; DOI=10.1038/nature04300;
RA   Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA   Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA   Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA   Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA   Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA   Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA   Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA   Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA   Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA   Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA   Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA   Kikuchi H.;
RT   "Genome sequencing and analysis of Aspergillus oryzae.";
RL   Nature 438:1157-1161(2005).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of ndc80, nuf2,
CC       spc24 and spc25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP007155; BAE57720.1; -; Genomic_DNA.
DR   RefSeq; XP_001819722.1; XM_001819670.1.
DR   AlphaFoldDB; Q2UL45; -.
DR   SMR; Q2UL45; -.
DR   STRING; 510516.Q2UL45; -.
DR   EnsemblFungi; BAE57720; BAE57720; AO090003000554.
DR   GeneID; 5991705; -.
DR   KEGG; aor:AO090003000554; -.
DR   VEuPathDB; FungiDB:AO090003000554; -.
DR   HOGENOM; CLU_012583_0_0_1; -.
DR   OMA; IRFKVHV; -.
DR   Proteomes; UP000006564; Chromosome 2.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..736
FT                   /note="Probable kinetochore protein ndc80"
FT                   /id="PRO_0000246633"
FT   REGION          28..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          53..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          325..492
FT                   /evidence="ECO:0000255"
FT   COILED          586..688
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        53..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   736 AA;  83600 MW;  18156FBBFAB66B00 CRC64;
     MSQDTGLFSI KRPRESLAHF SALPQPSSAL KRTSSIGAFG NPPTAQHTRM SLLNSASRPQ
     QPNFQRSSSG GAFGADAGLS SVRRSVSSNI FHGASAGRQS YAPGSFSSNP ASQNLQRRSS
     VFSRPSAGVG GAMGHQSFFT QVPNAAGVPR DPRPLRDRSF QARIGQELLE YLTHNNFELE
     MKHTLGQNTL RSPTQKDFNY IFQWLYHRID PGYRFQKSMD AEVPPILKQL RYPYEKGITK
     SQIAAVGGQN WPTFLGMLHW LMQLAQMMDR FIMGEYDEAC AEAGVDVSGD RIIFRFLTGA
     YHDWLQGGED EDDETAGQRL VPHIEMMAQE FERGNEKYVQ EVQALEAENR ALRDQIEEME
     KSAPDMAKLD KHFRILEDDK RKFEDYNQNV QGKIEKYENR IKFLEDELQK TEADLQAAED
     ERAGLQSSVD RQGITIQDID RMNTERDRLQ KILDDTMGRL EETHSRVMEK EKEASEKLEA
     LEEVVKAYNT LGYQTSLIPS SAVNAKGQDY ELSLNVNESN FSASQIGSAP SRISPEGDRL
     LAEPFTGYHP AHLLSLDLRG TVRSSLQTLR KDINERRKRA ADDDLDRRNL LDNIKEAMDE
     KRSEVEALEH RRRAAEEEFE RTKEITTTQK LASDAQIEKM EKELAKMRAT MSESVQLMEQ
     REMNTNIEYE QLTLRANALR EELHTNVESM LNDVIRFKVH VQKGLEDYEG FVVDEVEQEL
     GGDMVPADDI PPEEEL