ID   NDC80_CANAL             Reviewed;         788 AA.
AC   Q5A216; A0A1D8PSA2;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable kinetochore protein NDC80;
GN   Name=NDC80; OrderedLocusNames=CAALFM_CR02680WA;
GN   ORFNames=CaO19.10345, CaO19.2827;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31011.1; -; Genomic_DNA.
DR   RefSeq; XP_715758.2; XM_710665.2.
DR   AlphaFoldDB; Q5A216; -.
DR   SMR; Q5A216; -.
DR   BioGRID; 1225642; 1.
DR   STRING; 237561.Q5A216; -.
DR   PRIDE; Q5A216; -.
DR   GeneID; 3642573; -.
DR   KEGG; cal:CAALFM_CR02680WA; -.
DR   CGD; CAL0000189198; orf19.10345.
DR   VEuPathDB; FungiDB:CR_02680W_A; -.
DR   eggNOG; KOG0995; Eukaryota.
DR   HOGENOM; CLU_012583_1_0_1; -.
DR   InParanoid; Q5A216; -.
DR   OrthoDB; 881626at2759; -.
DR   PRO; PR:Q5A216; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..788
FT                   /note="Probable kinetochore protein NDC80"
FT                   /id="PRO_0000246634"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          66..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          155..205
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          346..788
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        155..199
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        566..580
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   788 AA;  92450 MW;  2D5432A8D7719FB4 CRC64;
     MSQTSNPIYG LRRNNGFAGG SNPSNNNNNN SNNNHNGNRI SLGSATRTSS IISNNLPFRQ
     SLLHGNYDNA INNTPSTSSL QKQSQQQQQS SQTSQTKRRS TLLSTPATTT KRRQSMMGNN
     LHQQHQYGST ALRHSTQPSS SMNSQFNQAL QHVSPYYNPT SYSSQTPSSQ PSSQQYQQQQ
     QQANIPSSAS SSQQQQSMDP RPLKDKKYQE LIQKEIIRYL IDYKFEIKTN IALTENILKS
     PTQKNFNAIF KFLYNQLDPN YMFIKSSIEQ EIVTLLKLLN YPYMHTITRS HFSAVGGNNW
     PTFLGILYWL VELNLSLSTL NDDDFLADDD FDKIFIEYIW KSYSLFINDE EEEEQQQQEQ
     QQQANNGGSG GGGGDKFYND MKIKFDQLQE KLNQELNNVE QQHENLLNKY HELNNQLKIR
     DDALKKTVAL EEDYMKLKSY NQNVEKMMPE WNKKLEQLSN EVISYEEQMN KLQDEKKSIE
     MDLQQRGISI DKVNELYIKR DQLSKSIEII SNKIDDLKEK LSGRSFDLEK NFDNLENLTN
     QYNEITNKFN YYYYQQIQQN QQQDQQQQEE EEEEEEEEEH QLIPQFGLKL DENIKTTNER
     RQFTRDEIFL NINVKQERQN LLNFRNELDH QILNDRSQAM KFNEKCDIEQ DKIKDQQSII
     EELKIQDSLM KRKSDDLKQT IFQIQNEFNS QIESLDQQIR ETKSNIQSDI LQLERKLRDV
     NLNKSLIQEQ LIGKRQKIDE DVINLTSFIL KFKTNIQEKL INIADIVQDQ LKKEQQQQQQ
     QQASQQLE