ID   NDC80_CANGA             Reviewed;         706 AA.
AC   Q6FW62;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable kinetochore protein NDC80;
GN   Name=NDC80; OrderedLocusNames=CAGL0D02684g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR   EMBL; CR380950; CAG58443.1; -; Genomic_DNA.
DR   RefSeq; XP_445532.1; XM_445532.1.
DR   AlphaFoldDB; Q6FW62; -.
DR   SMR; Q6FW62; -.
DR   STRING; 5478.XP_445532.1; -.
DR   EnsemblFungi; CAG58443; CAG58443; CAGL0D02684g.
DR   GeneID; 2887182; -.
DR   KEGG; cgr:CAGL0D02684g; -.
DR   CGD; CAL0128305; CAGL0D02684g.
DR   VEuPathDB; FungiDB:CAGL0D02684g; -.
DR   eggNOG; KOG0995; Eukaryota.
DR   HOGENOM; CLU_012583_1_2_1; -.
DR   InParanoid; Q6FW62; -.
DR   OMA; IRFKVHV; -.
DR   Proteomes; UP000002428; Chromosome D.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR   GO; GO:0008017; F:microtubule binding; IEA:EnsemblFungi.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblFungi.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR040967; DUF5595.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF18077; DUF5595; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..706
FT                   /note="Probable kinetochore protein NDC80"
FT                   /id="PRO_0000246635"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          402..472
FT                   /evidence="ECO:0000255"
FT   COILED          553..669
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   706 AA;  81821 MW;  ECD5782047DAC959 CRC64;
     MPNEQSEASV LSRLNPHRFT TQIPQHPLSQ NMQRRRNSVS SAASDSINSL KQSSARAVSN
     SNGIQKNNKK YMRSTVAGAS GILPTYNKSM SFSQNKNLDD NNMRASLPVL ERDLNANNFK
     SANNNPIGFS SFSQPYSGSR DPRPLRDKNF QSAIQQEIFD YLIQNTFEID TNYPISLKTL
     KQPTQKSFVT IFKWLYLRLD PGYTFTKSIE YEVYQLLKIL QYPYLESINK SQISAVGGSG
     WPKFLGMLHW LVTINLRLDK CLNTLDQNLL NQQTQDLTTL SKPVENIEDQ EVRQEKYELM
     AERLFIDYIT DSYKTFLNLK DDYSDHMNEL KAGFERYLHI IKLDVNNIQS KNENMFEKFE
     ISRNRVEKLK VARGKSTALN GDLVKFQKYV DSMKAKSEEW PIKLSKIEDE LNEKKENIKL
     ITEEISQIQD SLQRKGLSVE QIENKNEQKL QLEKEIDQIA EKADEFVSLI KSTKVDNEKV
     FVTFQDSIRQ YNDLLLEFLT SRRKLGHDIE IEPLKITLPN EVVVPNSENA LTMDKLFPTD
     HPMPEYYQNM LLSINSDIMK RIETLKTDNQ ELEREIGMLT EEINSRGSTN ESLELKLSDL
     NLNLKNVRQE NRAEILAQSL EIEKLERQIT EGNKNIEQKI ANAERIVTEL LNEKEVLYNE
     HSKFKSDLNL KIQKLIKEAH SLRFAVKDST NRLNELIFTE SSETDD