ID   NDC80_CRYNJ             Reviewed;         703 AA.
AC   P0CP16; Q55SB3; Q5KGR0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Probable kinetochore protein NDC80;
GN   Name=NDC80; OrderedLocusNames=CNE02670;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC       NDC80, NUF2 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR   EMBL; AE017345; AAW43664.1; -; Genomic_DNA.
DR   RefSeq; XP_570971.1; XM_570971.1.
DR   AlphaFoldDB; P0CP16; -.
DR   SMR; P0CP16; -.
DR   STRING; 5207.AAW43664; -.
DR   PaxDb; P0CP16; -.
DR   eggNOG; KOG0995; Eukaryota.
DR   HOGENOM; CLU_012583_1_1_1; -.
DR   InParanoid; P0CP16; -.
DR   OMA; IRFKVHV; -.
DR   OrthoDB; 925552at2759; -.
DR   Proteomes; UP000002149; Chromosome 5.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..703
FT                   /note="Probable kinetochore protein NDC80"
FT                   /id="PRO_0000246636"
FT   REGION          1..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          326..358
FT                   /evidence="ECO:0000255"
FT   COILED          407..479
FT                   /evidence="ECO:0000255"
FT   COILED          573..616
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        7..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..66
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        103..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   703 AA;  78423 MW;  D6D6DDD743F4C71B CRC64;
     MDFRRQTLVS NGGSSQPQPS VPSSAIKKAS RLGPARQSLA PSQIQSRTSI LGVSNSQENA
     SHGMMGSRKS TVPGKMGDRD QLMSASRGDG GIYGRTPQMN RGIPGSVRRS SVFTSNSQGR
     TSMAPGVYST AYKDPRPLRD KVFQSNCMRN VNEYLISVRY PLPLTAKTLT SPTAKEFQSI
     FKFLVNDLVD PGAAWGKKFE DDTLSILKDL KYPGMDSVSK TALTAPGAPQ SWPNMLAMLN
     WLVDLCKALD NWDDPEIISD PLMVPATELP LDYPNLDDRL LWDFAAKTYS QWFDGEAEEF
     DEAEQELEHA YGKSYSIVLN DTEQATDRMA SATVAECEKL EREIQKRNVE IQQLHVQEVC
     SPITDRISFA DKSYKPPLKK LEDEYVQLMS DKNKFISFLD QQGQKIEKIR LRISKVKEAV
     ISQEAELEAR QSELAHIEQA VAAQNLSPDE VQRMNHERDS LTRSLEDLRN KISEASQFAY
     DQEMVVTKSM DRFEGLLTDY NSLAHQIGLL DSSLDVPSLA ANVNYNLDVD LGAEELEEVK
     AVGVRMRSTI WQALQTCRET FRQEALGLGN GTIALEDEFD KLGQSVERQK EEVGNLEVRL
     KIVHNQAEDA QSQIASENSD TNKIITQLET EVTNMLAASQ QGVLSTQSQL ESTRIAFKEL
     RHKTALFQDS VVAEVGEHID AIIKAKEHTA NSLKSIRALA ETQ