ID   NDC80_DEBHA             Reviewed;         650 AA.
AC   Q6BPZ9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Probable kinetochore protein NDC80;
GN   Name=NDC80; OrderedLocusNames=DEHA2E09548g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382137; CAG87957.2; -; Genomic_DNA.
DR   RefSeq; XP_459721.2; XM_459721.1.
DR   AlphaFoldDB; Q6BPZ9; -.
DR   SMR; Q6BPZ9; -.
DR   STRING; 4959.XP_459721.2; -.
DR   PRIDE; Q6BPZ9; -.
DR   EnsemblFungi; CAG87957; CAG87957; DEHA2E09548g.
DR   GeneID; 2902791; -.
DR   KEGG; dha:DEHA2E09548g; -.
DR   VEuPathDB; FungiDB:DEHA2E09548g; -.
DR   eggNOG; KOG0995; Eukaryota.
DR   HOGENOM; CLU_012583_1_0_1; -.
DR   InParanoid; Q6BPZ9; -.
DR   OMA; IRFKVHV; -.
DR   OrthoDB; 925552at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR040967; DUF5595.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF18077; DUF5595; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..650
FT                   /note="Probable kinetochore protein NDC80"
FT                   /id="PRO_0000246637"
FT   REGION          43..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          265..443
FT                   /evidence="ECO:0000255"
FT   COILED          510..601
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   650 AA;  76023 MW;  AD76B8F152ADEC01 CRC64;
     MNVDYPMNNI PQASSLLRKN NGKRLSMASA ARTSLLGNLN LNGTSGGASG RNSNIIDSSS
     LSMGNTGKRR SLLSTPASIN RRRQSSLLQA PMSSSQMSSQ SQQASQQTQA PFNQDQRPLR
     DKNYQTLIQQ EIYDFLLANK FELEMNHPLT FKTLKQPTQK DFVVIFQFLY NKIDPYYRFT
     KSIETEVFLL LKILNYPYLD GINRSQISAV GGQNWPNFLG MLYWLVKLNL SVLNLNSKVD
     LISPDDEFDK IFINYITQSY RAFIDERDDY SEYYDEMKSR FDELNNNIIQ DIENISNENN
     ELLNQYNELN GQLDILENSE KKSKALENDL IKFKAYIETM ESRKSKWSEI LNKITQEIGN
     CEVELNNIES VKRDYEAQIG QQGLTPNDID NLNTERDKLS KSIDLISNSL EDLKDVYHNK
     QINLQKNYQS LENFLKQYNN LIYKIQLKNH NYDYNFEINF RNNTIINETP DLLKPNEIIN
     KNLKDEKIQL LNYKSIINTN VHMHQDEQIK LQEQIDLISE LIMERREEIE TLEAKLTANK
     STYDEIYETM INDTTTYSMQ IEKLERELRS IKINTNQGFI EVENKFQNIQ IEYDELLYEI
     HSNRSILHDK IQKIIESTIG FKINIQSNLE DLENLAFDEF EKEDKKLNKN