NDC80_EMENI
ID NDC80_EMENI Reviewed; 738 AA.
AC Q5B3B1; C8V902;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Probable kinetochore protein ndc80;
GN Name=ndc80; ORFNames=AN4969;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of ndc80, nuf2,
CC spc24 and spc25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR EMBL; AACD01000084; EAA61047.1; -; Genomic_DNA.
DR EMBL; BN001303; CBF76372.1; -; Genomic_DNA.
DR RefSeq; XP_662573.1; XM_657481.1.
DR AlphaFoldDB; Q5B3B1; -.
DR SMR; Q5B3B1; -.
DR STRING; 162425.CADANIAP00005426; -.
DR EnsemblFungi; CBF76372; CBF76372; ANIA_04969.
DR EnsemblFungi; EAA61047; EAA61047; AN4969.2.
DR GeneID; 2872769; -.
DR KEGG; ani:AN4969.2; -.
DR VEuPathDB; FungiDB:AN4969; -.
DR eggNOG; KOG0995; Eukaryota.
DR HOGENOM; CLU_012583_0_0_1; -.
DR InParanoid; Q5B3B1; -.
DR OMA; IRFKVHV; -.
DR OrthoDB; 925552at2759; -.
DR Proteomes; UP000000560; Chromosome III.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0000775; C:chromosome, centromeric region; IDA:AspGD.
DR GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.30; -; 1.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; PTHR10643; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..738
FT /note="Probable kinetochore protein ndc80"
FT /id="PRO_0000246638"
FT REGION 20..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 329..492
FT /evidence="ECO:0000255"
FT COILED 582..689
FT /evidence="ECO:0000255"
FT COMPBIAS 20..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 84067 MW; B13599A85E883DA0 CRC64;
MSQDTGLFSI KRPRETLGSV QNFSSLPQPS SALKRTSSIG YQNPPFTSQH TRSMSLLNSV
GRPQQPNFQR SSSGGFGADP GLSSVRRSVS SNVFHGTSAG RPSFAPGSMS SNPASQSLQR
RSSVFSRPST GGAMGHQSFF TQVPSAAGVP RDPRPLRDRS FQARIAQELL EYLTHNNFEL
EMKHSLGQNT LRSPTQKDFN YIFQWLYHRI DPGYRFQKAM DAEVPPILKQ LRYPYEKGIT
KSQIAAVGGQ NWPTFLGMLH WLMELAQMMD RFAMGEYDEA CAEMGVDVSG DRIIFRFLTG
AYHDWLQGGE EEDDDAAAQR LIPHIELMAQ EFEKGNEKYV QEMQVLDAEN RALRDQIEEL
EKNAPDMAKL DKQFRILEDD KRKFEDYIQN VQGKIEKYES RIAFLEDEIR KTESELQAAE
EERAGLQASV DQQGLTIQDI DRMNTERDRL QRSLDDAVSR LEETHARVMA KESEASAKLE
DLEELVKTYN TLGYQNSLIP STAVNANGQE YELGLNVNER SFSTSQIGGI PSRISPEADR
LLAEPFTGYH PAHLLNLDLR GIVRSNLQAL RKEINERRKR GIDADLERRN LLDNIKEAMD
EKRSEVEALE HKRRTAEEEF ERLKEVTTTQ KLASDAQIEK MEKELAKMRA TMSESVQLME
QREMNTNIEY EQLTLRANAL REELHTNVES MLNDVIRFKV HIQKGLEDYE NFVVDEVEQE
LGGDTQLDED APMSTEEL
