ID   NDC80_ENCCU             Reviewed;         543 AA.
AC   Q8SUE9;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Probable kinetochore protein NDC80;
GN   Name=NDC80; OrderedLocusNames=ECU10_0810;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of at least
CC       NDC80 and NUF2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR   EMBL; AL590449; CAD25800.1; -; Genomic_DNA.
DR   RefSeq; NP_586196.1; NM_001042029.1.
DR   AlphaFoldDB; Q8SUE9; -.
DR   SMR; Q8SUE9; -.
DR   STRING; 284813.Q8SUE9; -.
DR   GeneID; 859845; -.
DR   KEGG; ecu:ECU10_0810; -.
DR   VEuPathDB; MicrosporidiaDB:ECU10_0810; -.
DR   HOGENOM; CLU_012583_1_0_1; -.
DR   InParanoid; Q8SUE9; -.
DR   OMA; MNGADSF; -.
DR   OrthoDB; 925552at2759; -.
DR   Proteomes; UP000000819; Chromosome X.
DR   GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:InterPro.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..543
FT                   /note="Probable kinetochore protein NDC80"
FT                   /id="PRO_0000246639"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          203..356
FT                   /evidence="ECO:0000255"
FT   COILED          450..483
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..17
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  63097 MW;  766E049A533CEC8C CRC64;
     MTRRFTMTPN SRNPVKTPVS GMKVAPFPRH SIATEEVRRR DMRVVREKGY RQQCVDGILR
     FLVENGYDGQ VSQKILHNPS SKDFQSIFKF LYGFVDDFTF SSRFEDEVVN VMKNLKYPYC
     GEITKSQLSA ITPHTWPVIL SMCSWLVDLI SHGTSLLQQE EERSVESCFF EYVCDGYMRF
     MEGDEDDTAL EEEFERRVTE IYTGIFKEID RKKEELRRIE EMISEARKMS EGREELDRKK
     RELTDDLNML IASEKQLEGK KRKYLGAISR LSEEIVKVEE EIESLRAQED GLRAQITKQR
     INPEDVKEMN AEKIELFKEL ERMKPEKESL MKVVGEQERE AQERAEEVEK LFFDLKGLRD
     EISLRIVKDG KGVPRVANEV SGEVFSGMSG VIVRLEEELN SKSDVLVTAE MNKSILEEAR
     GEKESITSEL NSRLGYYSDK LVMAGKLYLE KKEISENEQR KSKTEMELLE NELLKLNLES
     NTSLLMSEQK LQKARIVLDR TLNSINYERE EINKMIFGFY NAAMDIHASI QSQVGDLRAL
     LNK