NDC80_GIBZE
ID NDC80_GIBZE Reviewed; 726 AA.
AC Q4I0J6; A0A0E0SBB5; V6RV41;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2005, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Probable kinetochore protein NDC80;
GN Name=NDC80; ORFNames=FGRRES_09262, FGSG_09262;
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1;
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C.U., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC SPC24 and SPC25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR EMBL; DS231668; ESU15810.1; -; Genomic_DNA.
DR EMBL; HG970335; CEF83728.1; -; Genomic_DNA.
DR RefSeq; XP_011328506.1; XM_011330204.1.
DR AlphaFoldDB; Q4I0J6; -.
DR SMR; Q4I0J6; -.
DR STRING; 5518.FGSG_09262P0; -.
DR EnsemblFungi; ESU15810; ESU15810; FGSG_09262.
DR GeneID; 23556224; -.
DR KEGG; fgr:FGSG_09262; -.
DR VEuPathDB; FungiDB:FGRAMPH1_01G27527; -.
DR eggNOG; KOG0995; Eukaryota.
DR HOGENOM; CLU_012583_0_0_1; -.
DR InParanoid; Q4I0J6; -.
DR Proteomes; UP000070720; Chromosome 4.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.30; -; 1.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; PTHR10643; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..726
FT /note="Probable kinetochore protein NDC80"
FT /id="PRO_0000246640"
FT REGION 1..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 323..489
FT /evidence="ECO:0000255"
FT COILED 587..682
FT /evidence="ECO:0000255"
FT COMPBIAS 21..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 726 AA; 82885 MW; 9E8714B589B1E3DF CRC64;
MSQDTGLWSV RRPRETLGGI SANSAIPQPG STMKRSSSNI GGNYPGSHVR SMSGSRHSLA
MPRPSQPMFQ RSSSGTNLVD LGLSSVKRSS FAPKSTFTPG TATKRASTDG DRRSSVYRPR
QSTVPAVSHH QSFFQTTPAP AGVPRDPRPL KDRSFQARIG QEIMEYMVQH NFEMEMKHVL
SQNVLKSPTQ KDFNYMFQWL YHRIDPSHKF QKNIDQEVPP LLKQMRYPFE RSITKSQIAA
VGGQNWSTFL GLLHWMMQLA QMLDGYVNCQ YDEACMEAGI DVSGDRIIFD FLSNGYRDWL
AMDEDLGDEE AERVLAPHVQ SMAAAFERSN SKYTSELDML EAENARLLKE IEDLEKSTPD
PAVLDHHFKI MEEDKVKFEE YNALAMQRSE KYESRSQVLQ EELDKLLEEL QEADEERRSL
QKAVDAQGIS MQDIDRMTAE RERLQRGIES ASQRLEEVKK KVSEREAEAS RKLDELEQMV
DRYNTMAYQI ALIPSTAANA KGREFELQVT VADDSDFTTS IMKSGPSSAD RLVVDSTTGH
QAGHILNLDL RGKIRNSFIS LRKEISDRRA TAMDEMIKDH DLLDGIKEAI EDRRGEVEAL
NHRVRAAEEE YEKTKEVTTA QKLASDAHIE KMEKELSRMR AGLSENVQIL EQREINTTIE
YEQLVLQANA LREELHTEID RMLNDVIKFK IHVQKSLDDY EGFVTEELEK ELGSDEMQED
TQRMDM
