NDC80_KLULA
ID NDC80_KLULA Reviewed; 673 AA.
AC Q6CNF3;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 95.
DE RecName: Full=Probable kinetochore protein NDC80;
GN Name=NDC80; OrderedLocusNames=KLLA0E13035g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000250}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC SPC24 and SPC25. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR EMBL; CR382125; CAG99623.1; -; Genomic_DNA.
DR RefSeq; XP_454536.1; XM_454536.1.
DR AlphaFoldDB; Q6CNF3; -.
DR SMR; Q6CNF3; -.
DR STRING; 28985.XP_454536.1; -.
DR EnsemblFungi; CAG99623; CAG99623; KLLA0_E13003g.
DR GeneID; 2894656; -.
DR KEGG; kla:KLLA0_E13003g; -.
DR eggNOG; KOG0995; Eukaryota.
DR HOGENOM; CLU_012583_1_2_1; -.
DR InParanoid; Q6CNF3; -.
DR OMA; IRFKVHV; -.
DR Proteomes; UP000000598; Chromosome E.
DR GO; GO:0031262; C:Ndc80 complex; IEA:EnsemblFungi.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:EnsemblFungi.
DR GO; GO:0008017; F:microtubule binding; IEA:EnsemblFungi.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0034501; P:protein localization to kinetochore; IEA:EnsemblFungi.
DR Gene3D; 1.10.418.30; -; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; PTHR10643; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..673
FT /note="Probable kinetochore protein NDC80"
FT /id="PRO_0000246641"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 328..402
FT /evidence="ECO:0000255"
FT COILED 436..464
FT /evidence="ECO:0000255"
FT COILED 513..673
FT /evidence="ECO:0000255"
FT COMPBIAS 20..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 78517 MW; 7EDC77C5E4E2B3DE CRC64;
MDELRDIRTT GPEDVLNSVD PYRYTSQIPN GKSNNGLNAK MNGNNTLTNM INRSIAKNMG
QNASSGSMRR SMRQSLRNSL PRSSIGPQQQ QQMNSTQNST YHNTARDPRP LRDKNFQNLL
QQEIFSYLTD QKFDVETNHP ISLKSLKQPT QKDFIYMFKW LYLRLDPGYV FTKSLEHEVY
SILRTIHYPY LATINKSQIS AVGGSNWPKF VGMLHWLVII NKKLDECLEH LDVSINNQVT
QDITVLNQPL KTAEEQEKKQ EKYELMVERL FIDYITESYK SFLRLEDDYE PYLHDLELSF
QRFVHIIETD IAQLTSTTEH LSVECESIVA KNYELKNIKE KNTGLEQEYK RLSHGVQITQ
AKSKEWPDKL KEIEDEIDKK KRDIRQVSLQ IDELTSVLKR KNISGEEIEH KNKESDSISK
SLDTVSSRLD QFTGLVRQQR LETESVYKNL QDTLKQYKSA TEGLVIARKN LGDHIDESSI
ELVLPSDLMS EEMIGLTVEE LIGDKKSFTD PIKKNLNKIA EDIKMRITNI QTENSKLQIK
LEDLRNEITT KNEDLDQLEQ QLSSIKSEYE EYRQESQSQL LSQNIKIEKL ERKIQNARVE
SQQKISSIER EAEETRLKLE ELKLLQNRER LELHNKVIQL IEYVSNFKIN TQSSIEELQN
ATQKELQRLQ TEV