ID   NDC80_NEUCR             Reviewed;         743 AA.
AC   Q96U60;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Probable kinetochore protein ndc80;
DE   AltName: Full=Kinetochore protein 1;
GN   Name=kpr-1; Synonyms=ndc80; ORFNames=B23L21.070, NCU03899;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of kpr-1/ndc80,
CC       kpr-2/nuf2, kpr-3/spc24 and kpr-4/spc25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR   EMBL; AL356172; CAD11783.1; -; Genomic_DNA.
DR   EMBL; CM002241; EAA28302.3; -; Genomic_DNA.
DR   PIR; T49694; T49694.
DR   RefSeq; XP_957538.3; XM_952445.3.
DR   AlphaFoldDB; Q96U60; -.
DR   SMR; Q96U60; -.
DR   STRING; 5141.EFNCRP00000003729; -.
DR   EnsemblFungi; EAA28302; EAA28302; NCU03899.
DR   GeneID; 3873692; -.
DR   KEGG; ncr:NCU03899; -.
DR   VEuPathDB; FungiDB:NCU03899; -.
DR   HOGENOM; CLU_012583_0_0_1; -.
DR   InParanoid; Q96U60; -.
DR   Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..743
FT                   /note="Probable kinetochore protein ndc80"
FT                   /id="PRO_0000246642"
FT   REGION          42..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          88..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          326..493
FT                   /evidence="ECO:0000255"
FT   COILED          590..696
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        88..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   743 AA;  84855 MW;  3F57D6D286399718 CRC64;
     MSQDSNAGLW SVRRPRETLH GVNLTSGIPA PPSTLKRQST IGTIGTGHGR SLSGRQSLAL
     PRPSQPLFQR SSDIGLGSVK RASVHNMNTS QFKPYGTPGS SGIPRSSQEL DRRSSVYRPS
     ARPSAVGGGP LAGGHMSFFQ QAPQPAGVPR DPRPLKDRQF QNRIGQELLE YLAKNNFEME
     MNHKLSDNFT KSPTQKDFNY LFQWLYHRID PSYRFQKNID QEVPPLLKQL RYPYEKSITK
     SQIAAVGGQN WSTFLGLLHW MMQLAQMLEG YARHQYDDAC MEAGVDIAGD QIIFDFLTSA
     YQDWLNMDDE AGDEDVERAL QPHVQGMAEA FERSNAKYIQ ELEILEGENA RLLKEIQELE
     KSTPDPAILD NHFKIMEEDK IKFEEYNTLA MQRTEKYENR IQVLREELGK LHVELKEAEE
     ERRQMQKAVD DQGISMQDID RMTSERERLQ RSIESASQRL EDVKKKVAER EMEASQRLDE
     LERLVEKYNT VAYQIGLIPA TAVNAKGKNL ELQVTVNEGT PNFASSMQGV LGPNGQPLGG
     VENERLLADS TTGYQPAHIL NLDLRGQVKN TFLALRKEVS ERRKVAMDVM MEDHDLLDRA
     KEAIEDKRNE VEALGHRVRA AEEEYEKTKE VTNAQKMASD AQIEKMEKEL AKMRAQLSES
     VQLMEQREMN TNIEYEQLTL RANALREELH TETMRMLNDV IKFKMHVQRS LEEYETFVAD
     ELEQELGIDD QEMEDEDTPM ADV