NDC80_SCHPO
ID NDC80_SCHPO Reviewed; 624 AA.
AC Q10198;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 144.
DE RecName: Full=Kinetochore protein ndc80;
DE AltName: Full=NMS complex subunit ndc80;
GN Name=ndc80; Synonyms=ndc10, tid3; ORFNames=SPBC11C11.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION.
RX PubMed=11553715; DOI=10.1091/mbc.12.9.2767;
RA Kniola B., O'Toole E., McIntosh J.R., Mellone B., Allshire R.,
RA Mengarelli S., Hultenby K., Ekwall K.;
RT "The domain structure of centromeres is conserved from fission yeast to
RT humans.";
RL Mol. Biol. Cell 12:2767-2775(2001).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=12928332; DOI=10.1242/jcs.00707;
RA Appelgren H., Kniola B., Ekwall K.;
RT "Distinct centromere domain structures with separate functions demonstrated
RT in live fission yeast cells.";
RL J. Cell Sci. 116:4035-4042(2003).
RN [4]
RP IDENTIFICATION IN THE NDC80 COMPLEX, IDENTIFICATION IN THE NMS COMPLEX, AND
RP SUBCELLULAR LOCATION.
RX PubMed=16079914; DOI=10.1038/sj.emboj.7600762;
RA Liu X., McLeod I., Anderson S., Yates J.R. III, He X.;
RT "Molecular analysis of kinetochore architecture in fission yeast.";
RL EMBO J. 24:2919-2930(2005).
RN [5]
RP FUNCTION OF THE NDC80 COMPLEX, INTERACTION WITH NUF2; SPC24 AND SPC25, AND
RP SUBCELLULAR LOCATION.
RX PubMed=15728720; DOI=10.1091/mbc.e04-11-0996;
RA Asakawa H., Hayashi A., Haraguchi T., Hiraoka Y.;
RT "Dissociation of the Nuf2-Ndc80 complex releases centromeres from the
RT spindle-pole body during meiotic prophase in fission yeast.";
RL Mol. Biol. Cell 16:2325-2338(2005).
RN [6]
RP IDENTIFICATION IN THE NMS COMPLEX.
RX PubMed=17035632; DOI=10.1091/mbc.e06-05-0388;
RA Hayashi A., Asakawa H., Haraguchi T., Hiraoka Y.;
RT "Reconstruction of the kinetochore during meiosis in fission yeast
RT Schizosaccharomyces pombe.";
RL Mol. Biol. Cell 17:5173-5184(2006).
RN [7]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Acts as a component of the NMS (Ndc80-MIND-Spc7) super
CC complex which has a role in kinetochore function during late meiotic
CC prophase and throughout the mitotic cell cycle. Acts as a component of
CC the essential kinetochore-associated NDC80 complex, which is required
CC for chromosome segregation and spindle checkpoint activity.
CC {ECO:0000269|PubMed:15728720}.
CC -!- SUBUNIT: Component of the NDC80 complex, which consists of ndc80, nuf2,
CC spc24 and spc25. Component of the NMS super complex which consists of
CC mis12, mis13, mis14, ndc80, nnf1, nuf2, sos7, spc7, spc24 and spc25.
CC {ECO:0000269|PubMed:16079914, ECO:0000269|PubMed:17035632}.
CC -!- INTERACTION:
CC Q10198; Q10173: nuf2; NbExp=3; IntAct=EBI-1002524, EBI-1002565;
CC Q10198; Q9UST6: spc24; NbExp=3; IntAct=EBI-1002524, EBI-1002585;
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore.
CC Note=Associated with kinetochores.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA20685.1; -; Genomic_DNA.
DR PIR; T39318; S67382.
DR RefSeq; NP_596392.1; NM_001022313.2.
DR AlphaFoldDB; Q10198; -.
DR SMR; Q10198; -.
DR BioGRID; 276635; 18.
DR ComplexPortal; CPX-549; Ndc80 complex.
DR IntAct; Q10198; 4.
DR STRING; 4896.SPBC11C11.03.1; -.
DR iPTMnet; Q10198; -.
DR MaxQB; Q10198; -.
DR PaxDb; Q10198; -.
DR EnsemblFungi; SPBC11C11.03.1; SPBC11C11.03.1:pep; SPBC11C11.03.
DR GeneID; 2540097; -.
DR KEGG; spo:SPBC11C11.03; -.
DR PomBase; SPBC11C11.03; ndc80.
DR VEuPathDB; FungiDB:SPBC11C11.03; -.
DR eggNOG; KOG0995; Eukaryota.
DR HOGENOM; CLU_012583_1_0_1; -.
DR InParanoid; Q10198; -.
DR OMA; IRFKVHV; -.
DR PhylomeDB; Q10198; -.
DR PRO; PR:Q10198; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000775; C:chromosome, centromeric region; IDA:PomBase.
DR GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR GO; GO:0031262; C:Ndc80 complex; IDA:PomBase.
DR GO; GO:0031617; C:NMS complex; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; IC:PomBase.
DR GO; GO:0000940; C:outer kinetochore; IDA:PomBase.
DR GO; GO:0140463; F:chromatin-protein adaptor; IMP:PomBase.
DR GO; GO:0140483; F:kinetochore adaptor activity; EXP:PomBase.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IDA:PomBase.
DR GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IC:ComplexPortal.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IC:ComplexPortal.
DR GO; GO:0007094; P:mitotic spindle assembly checkpoint signaling; IC:ComplexPortal.
DR GO; GO:0051455; P:monopolar spindle attachment to meiosis I kinetochore; IDA:PomBase.
DR Gene3D; 1.10.418.30; -; 1.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; PTHR10643; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..624
FT /note="Kinetochore protein ndc80"
FT /id="PRO_0000116533"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 263..399
FT /evidence="ECO:0000255"
FT COILED 484..560
FT /evidence="ECO:0000255"
SQ SEQUENCE 624 AA; 71859 MW; 82EEC220635F5E7D CRC64;
MQDSSSYARR YSQAPSSSNL RTTTFGFNGL GTSRTSLAPQ RTLVNARQSI DPDGLSSRVL
TPTMRPSLAP NTRRSSVRVS NASFISQTPN ITSIKDPRPL SDRRYQQECA TQVVNYLLES
GFSQPLGLNN RFMPSTREFA AIFKHLYNKL DPNFRFGARY EEDVTTCLKA LNYPFLDSIS
RSRLVAIGSP HVWPAILGML HWVVSLIQCT EKAVAMVYTV EQNSLDDHLV DKVLFDYLVR
TYHLYLDESP EESEPEKELK ATFNQQNQDL YNQTEALKST NEELINQIKS AEELDSAIQV
LEERYRTMQR DEVKFQSAMS GMKSKMESRT NLMKQLQVNI EEKESQLQLL KEKRDSLKYQ
VENQDISISE FEKMVSEREQ LDRNLNMIGS KISELRKEVF DTDLLIQASI DSLEKKVQKF
NSLAYRIGIV PIAAIRSANN DFELEINPEG PNYINLDLKN KVRPFINEVR RSITLEFHEE
QNKSLKLQEH VDTVNDLIAE LQDELRGIES RLTSVLSECN MLRETASEEK NAFDAESDKL
ERELQQLKLS SHNSMLQLDQ RIQSINIEAD QIAHACMEYK NNIYKEVAFV LGEIIHFKLH
VQDSLEDLKM DYQKELDDLS RSEL