ID   NDC80_YARLI             Reviewed;         631 AA.
AC   Q6CEY7;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable kinetochore protein NDC80;
GN   Name=NDC80; OrderedLocusNames=YALI0B11814g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC       NDC80 complex, which is required for chromosome segregation and spindle
CC       checkpoint activity. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the NDC80 complex, which consists of NDC80, NUF2,
CC       SPC24 and SPC25. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere,
CC       kinetochore {ECO:0000250}. Note=Associated with kinetochores.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NDC80/HEC1 family. {ECO:0000305}.
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DR   EMBL; CR382128; CAG83025.1; -; Genomic_DNA.
DR   RefSeq; XP_500775.1; XM_500775.1.
DR   AlphaFoldDB; Q6CEY7; -.
DR   SMR; Q6CEY7; -.
DR   STRING; 4952.CAG83025; -.
DR   EnsemblFungi; CAG83025; CAG83025; YALI0_B11814g.
DR   GeneID; 2907301; -.
DR   KEGG; yli:YALI0B11814g; -.
DR   VEuPathDB; FungiDB:YALI0_B11814g; -.
DR   HOGENOM; CLU_012583_1_0_1; -.
DR   InParanoid; Q6CEY7; -.
DR   OMA; IRFKVHV; -.
DR   Proteomes; UP000001300; Chromosome B.
DR   GO; GO:0031262; C:Ndc80 complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.418.30; -; 1.
DR   InterPro; IPR005550; Kinetochore_Ndc80.
DR   InterPro; IPR038273; Ndc80_sf.
DR   PANTHER; PTHR10643; PTHR10643; 1.
DR   Pfam; PF03801; Ndc80_HEC; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Coiled coil;
KW   Kinetochore; Mitosis; Nucleus; Reference proteome.
FT   CHAIN           1..631
FT                   /note="Probable kinetochore protein NDC80"
FT                   /id="PRO_0000246643"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          321..387
FT                   /evidence="ECO:0000255"
FT   COILED          473..592
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        11..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   631 AA;  72294 MW;  3195C99362DF8253 CRC64;
     MNASAHKKRL SMMPGTSSAS RPSMAGLPQR NNPPPQREPA TPAVSELMRS SRRSMAFGRN
     PRQSSFGLVP QTPMAPMHTR DPRPVRDRHY QQQISQQIYE YLVTNHFEQE TRHPLNQRTL
     SNPTQKDFKT MFEWIFRRID PGYPFHKSIE NEVHAVLRAA KYPWLDSITK SQIVAVGGQS
     WAYFSGMLHW MVELNTTIEK YHNHDYSGDD GPSLVDEIFN RHARESYFAY LQGDDRFARP
     DAELCLAEEN AEFQEILAEQ RAQNPLPEGE DDELDEELSR LEAKWGKIEE AKLLGKNLAD
     DIVKLGAFVD ARKEHNARYA SQMSQATAEE DNVTSEVESL SRQKLKLQQT IQDQGLSPAE
     LDKLHLDMER QQKALNSLDE IIDEGRQVVS NKESTALAVF DALDRVIKEY TSSVLSYNAW
     VASDNDLPEI PESVYLIDLR EPLSEENLGR HPSVILGGVD PRNQIRPEIV RICNMVTSKV
     KALQEEALRL QEEIETNQEK LVSQKRHIGE LEAKSRRLRE TRNALEDSAS MNENENSQNT
     ERLENQFVQA QSETALAQSQ LKGLQVRLQD AEHERNKLSV EVQQARERLS QDILKQAEVM
     VAFKAMVQTK LQDFEMFVRA NVEEEIRGDH N