NDD_BPR32
ID NDD_BPR32 Reviewed; 152 AA.
AC P69190; P42266;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 29-SEP-2021, entry version 26.
DE RecName: Full=Nucleoid disruption protein;
DE AltName: Full=Nuclear disruption protein;
GN Name=ndd;
OS Enterobacteria phage RB32 (Bacteriophage RB32).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Tevenvirinae; Tequatrovirus.
OX NCBI_TaxID=45406;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=8163181; DOI=10.1016/0378-1119(94)90121-x;
RA Bouet J.-Y., Woszczyk J., Repoila F., Francois V., Louarn J.-M.,
RA Krisch H.M.;
RT "Direct PCR sequencing of the ndd gene of bacteriophage T4: identification
RT of a product involved in bacterial nucleoid disruption.";
RL Gene 141:9-16(1994).
CC -!- FUNCTION: Disorganizes the host nucleoid and inhibits replication, but
CC without host DNA cleavage or degradation. Only the architecture of the
CC nucleoid is affected. May act on the host chromosomal sequences that
CC determine the structure of the nucleoid. Binds to dsDNA but not to
CC ssDNA. {ECO:0000250|UniProtKB:P15556}.
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DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0098673; P:inhibition of host DNA replication by virus; IEA:UniProtKB-KW.
DR GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR InterPro; IPR009514; Phage_Ndd.
DR Pfam; PF06591; Phage_T4_Ndd; 1.
PE 3: Inferred from homology;
KW DNA-binding; Host-virus interaction;
KW Inhibition of host DNA replication by virus;
KW Modulation of host cell cycle by virus.
FT CHAIN 1..152
FT /note="Nucleoid disruption protein"
FT /id="PRO_0000164963"
SQ SEQUENCE 152 AA; 17147 MW; E03886AFF94DA5B4 CRC64;
MKYMTVTDLN NAGATVIGTI KGGEWFLGTP HKDILSKPGF YFLVSKLDGR PFSNPCVSAR
FYVGNQRSKQ GFSAVLSHIR QRRSQLARTI ANNNVPYTVF YLPASKMKPL TTGFGKGQLA
LAFTRNHHSE YQTLEEMNRM LADNFKFVLQ AY